Proteome Patterns May Betray Pathologic Aging

December 1, 2015
Proteome Patterns May Betray Pathologic Aging
Source: iStock/andipantz and ClinicalOMICs

Instead of hiding a rapidly aging portrait in his attic, a latter-day Dorian Gray might keep a proteomic profile tucked away in his files. This profile would capture all of Dorian’s pathologic peptidomic changes, while Dorian himself would suffer only normal peptidomic changes. Dorian would thus prolong his youthful appearance and vigor and perhaps attain the maximum human lifespan, 120 years or so.

Dorian wouldn’t even have to make a deal with the devil. Instead, he might simply avail himself of proteome-guided therapy. That’s the conclusion reached by scientists at the Leibniz Institute on Aging. These scientists, in collaboration with the Hannover-based biotechnology company Mosaiques Diagnostics and Therapeutics,” analyzed the urinary peptidomes of 1,227 healthy and 10,333 diseased individuals between 20 and 86 years of age. This work enabled them to detect molecular-level differences in normal and pathologic aging.

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