Paige Prostate Nabs First FDA Approval of AI-Based Pathology Tool for Cancer Dx
A clinical study evaluated by the FDA found that Paige Prostate improved detection of cancer on individual slide images by 7.3% on average when compared to pathologists’ unassisted reads for whole slide images of individual biopsies, with no impact on the read of benign slide images.
Cancer Vaccine Effectiveness May Lie in Reawakening Dormant T-Cells
MIT researchers revealed that vaccinating against certain neoantigens can boost overall T-cell response by reawakening dormant T cell populations that target those proteins and help shrink tumors in mice.
New Drug Targets for AD, ALS, and Parkinson’s Revealed by Brain Proteome Atlas
A genomic atlas of proteins found in the brain of Alzheimer’s disease patients has helped identify new targets for treating Alzheimer’s, Parkinson’s, ALS, and stroke; and 29 drugs, already approved by the FDA for other indications, could be used to target these conditions.
Leprosy Drug Shows Potential as At-Home Treatment for COVID-19
Clofazimine, which was discovered in 1954, is FDA approved and on the World Health Organization’s List of Essential Medicines. The drug’s utility for COVID-19 was initially identified by screening more than 12,000 drugs from the ReFRAME drug library.
More Precise NSCLC Treatment Selection Boosted by Using EGFR Mutation Structure and Function
Researchers from The University of Texas MD Anderson Cancer Center say that grouping epidermal growth factor receptor (EGFR) mutations by structure and function can help to better match non-small cell lung cancer (NSCLC) patients to the most promising treatments.
Small Sequencer Developer GenapSys Completes $90M Series C Financing
GenapSys’ sequencing system is about the size of an iPad, costs under $10,000, and is based on a proprietary direct electronic sequencing chip, which is intended to eliminate the need for cumbersome equipment.
Blood-Brain Barrier Disruption Promotes Tumor Lethality
Researchers found that blocking the activity of IL-6 at the blood-brain barrier increased the lifespan of fruit flies with cancer by 45% and also found that after 21 days, 75% of cancer-carrying lab mice treated with an IL-6 receptor blocker were alive, versus only 25% of untreated mice.
WHO Gaffe Releases Data Showing Remdesivir not Effective Against COVID-19
According to the draft, remdesivir had not reduced the presence of SARS-CoV-2 in the bloodstream of 158 patients treated with the antiviral candidate in the 237-patient trial and 18 patients were taken off the drug due to side effects.
Immunocore’s T-Cell Receptor Therapy Succeeds in Phase III
Immunocore's tebentafusp is the first T-cell receptor and the first systemic therapy that shows a significant survival benefit for patients with metastatic uveal melanoma, according to results from a Phase III trial.
COVID-19 Antiviral Candidate Targeting RNA Replicase Developed
U.S. researchers have developed an antiviral candidate drug targeting iron-sulfur clusters needed for SARS-CoV-2 RNA replicase to function properly and for the virus to reproduce successfully.
Long Reads Can Make Short Work of Rare Disease Diagnostics
Recent success stories bring hope that long-read sequencing may make diagnosing rare genetic disease more successful.
Top Women in Precision Medicine
Hailing from all corners of the globe, our 2021 list of influential women in precision medicine are scientists in the C-suite influencing the direction of the companies they help lead.
Powering Diagnostics for Infectious Disease
The COVID-19 pandemic saw a rush of companies developing diagnostics for the infectious disease that should benefit the detection of other diseases.
From Hype to Utility
Artificial intelligence is emerging from its overhyped past to provide analytical muscle in precision medicine.
Green Light Raises Red Flags
FDA, some experts at odds over agency’s accelerated approval for Aduhelm, the Alzheimer’s disease drug from Biogen and Eisai.
