Nucleosome, molecular model.

Epigenetic Changes Could Signal Increased Cancer Risk

The scientists found that allele-specific methylation was between 5- and 9-fold higher in cancer samples than in those taken from healthy controls—finding such methylation at 15,112 sites around the genome. Of these, 1838 were near sites that had already been linked to disease susceptibility.
Nucleosome, molecular model.

Epigenetic Changes Could Signal Increased Cancer Risk

The scientists found that allele-specific methylation was between 5- and 9-fold higher in cancer samples than in those taken from healthy controls—finding such methylation at 15,112 sites around the genome. Of these, 1838 were near sites that had already been linked to disease susceptibility.
Scientists working in laboratory

Pfizer, BioNTech COVID-19 Vaccine Construct Shows Promising Phase I/II Data

The companies said the preliminary data, plus additional preclinical and clinical data now being generated, will help them determine a dose level and select among multiple vaccine candidates for a global Phase IIb/III safety and efficacy trial.
3d rendered ovarian cancer illustration.

Remote Screening Test for Ovarian Cancer Receives Study Validation

Between 2016 and 2020, a clinical trial engaged nearly 4,000 women from all 50 US states with the intention to validate different combinations of remote genetic counseling—the first large, randomized study of its kind to attempt to do so for cancer risk.

NIH Consortium to Study Molecular Effects of Exercise

The National Institutes of Health-funded Molecular Transducers of Physical Activity Consortium (MoTrPAC) plans to measure molecular changes in healthy adults and children before, during, and after exercise, based on biospecimens provided by the volunteer participants.
Glioma - brain tumor

CAR-T Cell Therapy for Glioblastoma Shows Early Promise

The reported study data have led to the formation of a new start-up brain cancer immunotherapy company, Empirica Therapeutics, which aims to start clinical trials of the CD133-targeting CAR-T-cell therapy in recurrent glioblastoma patients by 2022.
investigators discover a rare genetic variant shown to protect people who carry known genetic risk factors for Alzheimer's disease

New Research Shows Why ApoE4 Increases Alzheimer’s Disease Risk

The researchers found that the lipid composition was healthy in the brain of mice with ApoE3 with sufficient amounts of unsaturated fatty acids and endocannabinoids. But when compared to the brain cells of E3, the E4 mice did not receive enough lipids.

Triple negative breast cancer might not actually be ‘breast cancer’

The study could signal a potential treatment breakthrough for patients with this form of breast cancer, which disproportionately affects and tends to develop more aggressively in black women.
DNA research concept DNA barcodes for biomedical research  mitochondrial DNA  Prostate cancer DNA test

New Research Details How Toxic Substance Exposure Can Cause Cancer

Scientists from the German Cancer Research Center and the Universities of Cambridge and Edinburgh have tracked the impact of the DNA-damaging chemical diethylnitrosamine to better understand how chemicals cause mutations in our cells’ DNA.
Amador County Wineries 9

SARS-CoV-2 Lineages in Northern California Arrived from Many Areas

It appears no one virus lineage was predominant in northern California, suggesting that transmission between communities was limited. Instead, virus introductions to the state were likely from people traveling from outside the studied counties and the state.
male scientist pipettes in lab

CRISPR Comes of Age—As a Diagnostic

Hailed for its gene editing power, Sherlock Bioscience’s COVID-19 diagnostic is the first CRISPR technology to gain FDA approval.Hailed for its gene editing power, Sherlock Bioscience’s COVID-19 diagnostic is the first CRISPR technology to gain FDA approval.
At Home Coronavirus Test

Five COVID-19 Test Developers to Watch

The coronavirus pandemic compels diagnostics companies to bring new assays, technologies to market.

’Omics in Translation

Proteomics and metabolomics may lag behind genomics in providing clinically actionable insights today, but the future is bright.
cloud ocmputing

Six Precision Medicine Companies Making Their Mark in 2020

This year’s list of innovative companies have all found, or developed, technology solutions that have allowed them to become innovators in their niche.
DNA, doctor using tablet

Keeping up with the Genomes

Molecular diagnostics providers seek ways to maintain services in a world consumed by COVID-19.
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