Study Finds Heart Drugs that Boost Cancer Immunotherapy Response
Preliminary findings from a trial involving cancer patients taking immune checkpoint treatment with PD-L1 inhibitors reveal that simultaneous treatment with angiotensin receptor II blockers (ARBs) improve patients’ responses.
Severe COVID-19 Activates Specific Set of T Cells
New research corroborates other studies that highlight potential associations between strong MAIT cell activation and severe COVID-19 outcomes and provide important information to help better understand the immune response to SARS-CoV-2 that could help develop new treatments.
Study Finds Heart Drugs that Boost Cancer Immunotherapy Response
Preliminary findings from a trial involving cancer patients taking immune checkpoint treatment with PD-L1 inhibitors reveal that simultaneous treatment with angiotensin receptor II blockers (ARBs) improve patients’ responses.
The Biological Link Between Periodontal Disease, Heart Inflammation Discovered
There are many connections between oral health and overall health besides diabetes, cardiovascular disease, and arthritis. The researchers’ findings may open a door of understanding for other inflammatory diseases and might even relate to COVID-19.
More European Coronavirus Sources in NYC COVID-19 Outbreak than First Reported
The research, conducted at NYU Langone Health, showed that the virus first took root in late February, seeded by at least 109 different sources that created chains of infection, and didn’t originate from a single "patient zero."
WHO: Remdesivir Has “Little or No Effect” as Hospital COVID-19 Treatment
The WHO’s Solidarity trial, a 405-hospital, 30-country open-label randomized trial among 11,266 hospital inpatients, also tested hydroxychloroquine, lopinavir (co-administered with ritonavir) and interferon regimens, which also failed to show effectiveness in hospital inpatients.
Simple Skin Test Shows Promise as Early Parkinson’s Disease Diagnostic
The study’s authors say that using the assay can lead to earlier detection of PD and, since it can identify patients with early onset of the disease, aid better recruitment for clinical trials.
Wide Variety in Accuracy of COVID-19 Antibody Tests Revealed
Researchers based at Kings College in London have discovered that commercially available antibody tests for COVID-19 vary widely in accuracy. The findings also revealed that some fast, lateral flow immunoassay tests, initially assumed to be less accurate, actually produced high quality results.
Synthetic Protein Could Be Effective COVID-19 Treatment
The ability to generate high-affinity Spike protein binders that block viral interaction with ACE2, but which are highly stable, and small—“to maximize the density of inhibitory domains”—could have multiple advantages over antibodies for direct delivery into the respiratory system.
Gut Hormone Identified that Plays Key Role in Parkinson’s Dementia
The team sought to determine whether unacylated-ghrelin (AUG) modulated hippocampal plasticity and memory function and whether plasma levels of acyl-ghrelin and UAG were associated with dementia in humans.
Prime Time for the Microbiome
With some positive results in the clinic, there are other encouraging signs the field is maturing and branching into other therapeutic areas such as oncology.
RNA for Medical Analysis
From Mendelian disorders to COVID-19, academic and industrial scientists use these nucleic acids to help diagnose diseases.
Top Women in Precision Medicine
In our second installment of women making their mark in the field, Clinical OMICs interviews Bonnie Anderson of Veracyte, Tina Hambuch of Invitae, and Cindy Perettie of Foundation Medicine.
Saving Baby Nathan
California Medicaid’s pilot program Project Baby Bear delivers better outcomes at lower cost via rapid whole-genome sequencing of critically ill newborns.
Payer Policies not Sole Reason for Inconsistent Utilization of Genomic Testing
A report from the Personalized Medicine Coalition found significant variability in the use of genomic testing for patients not only from state to state, but also within states.
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