The combination of Bristol-Myers Squibb (BMS)'s marketed cancer immunotherapies Opdivo (nivolumab) plus a low dose of Yervoy (ipilimumab) showed durable clinical benefit in a Phase II trial as a first-line treatment in patients with microsatellite instability-high (MSI-H) or DNA mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC)

Guardant Throws Hat in Early Cancer Detection Ring with CRC Test

Guardant Reveal, is a plasma-only ctDNA test for detection of early-stage colorectal cancer, with additional cancer types to follow. The minimal residue disease test, which will have a turnaround time of seven days, had been in development since 2016 under the name LUNAR-1, and was launched for research use only in 2019.
Researching vaccine to novel coronavirus 2019-nCoV. Close-up shot of a scientist preparing glass slide.

Regeneron, Moderna Return Encouraging Early Data on COVID-19 Clinical Trials

Moderna said its vaccine candidate produced neutralizing antibodies in older and elderly adults, while Regeneron said REGN-COV2 rapidly reduced viral load as well as time to alleviate symptoms in non-hospitalized patients.

Lab-on-a-Chip Infection Test Could Lead to Novel Portable Diagnostics

Dubbed TriSilix, the chip performs a miniature version of polymerase chain reaction (PCR) testing on bodily fluids, feces, or environmental samples, according to the scientists at Imperial College London who developed the new technology.
Healthcare: Medical students learn heart surgery procedure.

cfDNA Test Developed to Detect Acute Rejection After Heart Transplant

In studies of a group of 171 heart transplant recipients, the new blood test performed better than tissue biopsies, signaling problems even when no outward signs of rejection were evident.

Pacific Biosciences, Invitae to Codevelop Clinical WGS Platform

Leveraging both Sanger sequencing and long-read technology , PacBio and Invitae will look to develop new whole-genome assays in areas such as carrier screening, immune system response, and other heritable diseases.
How COVID-19 can damage the brain, the deterioration of myelin a fatty coating that protects neurons.

Neuroinvasion Mechanisms of SARS-CoV-2 Discovered

SARS-CoV-2 can affect many other organs in the body including the central nervous system, where the infection is associated with a variety of symptoms ranging from headaches and loss of taste and smell to impaired consciousness, delirium, strokes, and cerebral hemorrhage.
Triple negative breast cancer cell undergoing retraction and apoptosis

Researchers Activate Antiviral Immune Pathways in Triple Negative Breast Cancers

The study shows that endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection.
Antibodies responding to covid-19 coronavirus, illustration

Nanomaterial-Based Biosensor Can Detect COVID-19 Antibodies in Seconds

A big advantage of the new sensor is that it only requires a very small amount of blood—around 5 microliters—to work. It can also detect levels of antibodies as low as 0.15 nanograms per milliliter.
Illustration of a blood clot showing a clump of red blood cells intertwined in a fibrin mesh

Autoantibodies in COVID-19 Promote Blood Clots

About half of the patients who were very sick with COVID-19 were exhibiting a combination of high levels of both the dangerous antibodies and super-activated neutrophils, which are destructive, exploding white blood cells.
3d illustration of a cancer cell in the process of mitosis

Cancer Slows Down Cell Division to Weather Chemotherapy, Then Resumes Activity

By entering and leaving a dormant state in a coordinated fashion, the cancer cells can defeat a round of chemotherapy—and gain enough time to acquire resistance to additional rounds of chemotherapy.
Fetus with DNA ambilocal chord

NIPT Builds on Its Success

With guidelines for noninvasive prenatal testing expanding and payers reimbursing for these screenings, researchers search for new testing methods. Noninvasive prenatal testing brought genetics to the very core of clinical practice.

Genetic Counseling for All

In the 1990s, Elissa Levin proposed a master’s thesis on using the Internet to extend the reach of genetic counselors. Quickly, her committee shut...
Scientists Loading Centrifuge

Testing Conundrum

When Congress reconvenes in January, the lengthy docket of action items is expected to include proposed solutions to the years-long conundrum over how to...
Glowing Blue Honeycomb

Seeing Real-Time Biological Interactions with Graphene Transistors

Michael Heltzen, CEO and co-founder of Cardea Bio, a San Diego startup integrating tiny bits of biology into modern electronics, believes that the way...
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