Biogen’s adeno-associated virus-based gene therapy for treatment of the degenerative blindness choroideremia has failed at Phase III, the second ophthalmic gene therapy trial to fail for the company.
The analysis from the Human Genome Sequencing Center at Baylor College of Medicine revealed nearly 77% of the discordant variants were clustered within sections of the genome with known assembly problems that the researchers called DISCordant Reference Patches (DISCREPs).
The researchers described how different dispersal strategies can lead to the long-term persistence of human gut microbes which has implications for gut flora modulations.
While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
Findings from researchers at the University of Pennsylvania Perelman School of Medicine suggest that genetic mutations are not the only drivers of cancer spread; single-cell RNA profiling results underscore that gene expression patterns play a key role in disease outcomes.
A population genotyping assay with DNA probes that capture globally diverse genetic variants has been launched by Twist Bioscience, in colloration with the Regeneron Genetics Center, to help improve the diversity of human genomics research.
Upon regulatory approvals, Novavax said, it is on course to reach manufacturing capacity of 100 million doses per month by the end of the third quarter and 150 million doses per month by the end of the fourth quarter.
Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s disease (AD) and other tauopathies, but this study aimed to reveal more about how neuroanatomical connections, spatial proximity, and regional vulnerability affect this process.
While scientists know that tumors accumulate fats and that the accumulation is associated with immune dysfunction, the details of the relationship were not fully understood. The new findings suggest that the tumor microenvironment contains an abundance of oxidized fat molecules that suppress killer T cells’ ability to kill cancer cells when ingested.
Inhibiting bacterial hydrogen sulfide production can help improve antibiotic efficacy by reducing the ability of bacterial species such as Staphylococcus aureus and Pseudomonas aeruginosa to tolerate exposure to antibacterial drugs.