Beaty woman clor eye closeup supermacro background

Biogen Announces Phase III Failure for Degenerative Blindness Gene Therapy

Biogen’s adeno-associated virus-based gene therapy for treatment of the degenerative blindness choroideremia has failed at Phase III, the second ophthalmic gene therapy trial to fail for the company.
Point mutation, illustration

Comparison of Reference Genomes Uncovers 206 Variant Discrepancies

The analysis from the Human Genome Sequencing Center at Baylor College of Medicine revealed nearly 77% of the discordant variants were clustered within sections of the genome with known assembly problems that the researchers called DISCordant Reference Patches (DISCREPs).
Gut bacteria , gut flora, microbiome. Bacteria inside the small intestine, concept, representation. 3D illustration.

Researchers Detail Evolution, Persistence of the Human Microbiome

The researchers described how different dispersal strategies can lead to the long-term persistence of human gut microbes which has implications for gut flora modulations.

Sponsored: Making NGS Actionable—Moving Oncology Beyond ‘One Mutation-One Drug’

While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
Tumor - Cancer cells reproduction

Researchers Trace Metastatic Cancer Lineage, Gene Expression Patterns at Single Cell Level

Findings from researchers at the University of Pennsylvania Perelman School of Medicine suggest that genetic mutations are not the only drivers of cancer spread; single-cell RNA profiling results underscore that gene expression patterns play a key role in disease outcomes.
World map, illustration

Twist Develops Diverse Genotyping Option with Regeneron Genetics Center

A population genotyping assay with DNA probes that capture globally diverse genetic variants has been launched by Twist Bioscience, in colloration with the Regeneron Genetics Center, to help improve the diversity of human genomics research.

Novavax Eyes Q3 FDA Filing for its COVID-19 Vaccine

Upon regulatory approvals, Novavax said, it is on course to reach manufacturing capacity of 100 million doses per month by the end of the third quarter and 150 million doses per month by the end of the fourth quarter.
Alzheimer: Phosphorylation of Tau proteins leads to disintegration of microtubuli in a neuron axon

New Insights on Tau’s Spread in Brain and Impact of Genetic Risk Revealed

Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s disease (AD) and other tauopathies, but this study aimed to reveal more about how neuroanatomical connections, spatial proximity, and regional vulnerability affect this process.
White blood cells, T lymphocytes or natural killers T attack a cancerous or infected cell 3D rendering illustration isolated on black background. Science, medicine, biomedical research, immune system, oncology, biology concepts.

“Bad” Fat Hinders Killer T Cells’ Ability to Fight Cancer

While scientists know that tumors accumulate fats and that the accumulation is associated with immune dysfunction, the details of the relationship were not fully understood. The new findings suggest that the tumor microenvironment contains an abundance of oxidized fat molecules that suppress killer T cells’ ability to kill cancer cells when ingested.
MRSA bacteria or superbug

Targeting Hydrogen Sulfide Production Could Help Fight Antibiotic Resistance

Inhibiting bacterial hydrogen sulfide production can help improve antibiotic efficacy by reducing the ability of bacterial species such as Staphylococcus aureus and Pseudomonas aeruginosa to tolerate exposure to antibacterial drugs.

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