Image on screen of cancer screen. Artificial intelligence (AI) can be used in software that helps a pathologist interpret features of cancer in digitized images of samples.

AI For Cancer Detection: Ready for Prime Time or Caution Advised?

AI-based cancer imaging diagnostics have improved enormously over the last few years, with some programs already in use in the clinic, but researchers advise caution with more widespread rollout until more large-scale testing is completed.
Brain tumour, illustration

Location and Spread of Brain Metastases Linked to Primary Cancer Origin

The USC researchers found that bilateral temporal/parietal and left frontal lobes are susceptible to lung cancer, right frontal and occipital lobes to melanoma, cerebellum to breast cancer, and brainstem to renal cell carcinoma. 
3d illustration proteins with lymphocytes , t cells or cancer cells

Takeda, Jounce Drug Candidate Mobilizes Immunity by Suppressing SUMOylation

SUMOylation is a biochemical process that peppers proteins with small ubiquitin-like modifiers (SUMOs). Earlier studies have shown SUMOylation suppresses type I interferon (IFN1) signaling that helps mobilize innate and acquired immune response against cancer.
Beaty woman clor eye closeup supermacro background

Immunocore’s T-Cell Receptor Therapy Succeeds in Phase III

Immunocore's tebentafusp is the first T-cell receptor and the first systemic therapy that shows a significant survival benefit for patients with metastatic uveal melanoma, according to results from a Phase III trial.
Neuroblastoma cell line labeled with fluorescent molecules

New Potential “Double Target” Immunotherapy in Neuroblastoma Uncovered

A new immunotherapy using modified cells targeting two different antigens was highly effective in a mouse model of human neuroblastoma, according to a study led by researchers from the UNC Lineberger Comprehensive Cancer Center and the UNC School of Medicine.
Angiogenesis

Two Proteins that Promote Vascular Development in Breast and Liver Tumors Could be New...

Peptidylarginine deiminase 4 (PADI4) and hypoxia-inducible factor 1 (HIF-1) ramp up their activity under low-oxygen conditions that are typically found in a fast-growing tumor, to allow the formation of new blood vessels that feed the cancer’s growth.
Conceptual image for viral ethiology of prostate cancer

Paige Prostate Nabs First FDA Approval of AI-Based Pathology Tool for Cancer Dx

A clinical study evaluated by the FDA found that Paige Prostate improved detection of cancer on individual slide images by 7.3% on average when compared to pathologists’ unassisted reads for whole slide images of individual biopsies, with no impact on the read of benign slide images.
Image of researchers in a lab adding samples to a Helix sequencing machine.

Helix, MUSC to Launch Population Health Genomics Initiative in South Carolina

A new genomics program in South Carolina will enroll 100,000 volunteers over 4 years who will undergo exome testing to provide useful health information to the patients and their clinicians from the start, while also contributing to medical research.
Coronavirus, virus, flu, bacteria close-up. Abstract 3D rendered illustration

COVID-19 Antibodies Derived from Llamas Show Therapeutic Potential

The nanobodies, which bind tightly to the SARS-CoV-2 virus, neutralizing it in cell culture, could provide a cheaper and easier to use alternative to human antibodies taken from patients who have recovered from COVID-19.
Brain tumor illustration

Researchers ID Immunotherapy Target for Brain Metastases from Breast Cancer

The survival of women with brain metastases from breast cancer remains very poor, with over 80% dying within a year of their diagnosis. The researchers identified the protein IL13Ra2 as a target, with its known vulnerability to CAR T-cell treatment in clinical trials on brain tumors.

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