Alzheimer's disease: the amyloid-beta peptide accumulates to amyloid fibrils that build up dense amyloid plaques.

People With Down’s Syndrome At Risk of Early Alzheimer’s Disease

People with Down’s syndrome have an earlier and more substantial build-up of amyloid plaques and tau protein in the brain than people without the genetic condition, making them vulnerable to early Alzheimer’s disease.
Migrating breast cancer cell, illustration

UVA Researchers ID Gene Responsible for Triple-Negative Breast Cancer Metastasis

The team has also developed a nanoparticle-delivered antibody that they hope could possibly address both triple-negative breast cancer (TNBC) metastasis and resistance to treatment. They estimate that the strategy of blocking the culprit gene, TRIM37, could benefit approximately 80% of TNBC patients.
Antibodies responding to covid-19 coronavirus, illustration

Regeneron’s COVID-19 Antibody “Cocktail” Granted Emergency Use Authorization by FDA

Before patients can be treated with REGEN-COV2 under the EUA, they must weigh at least 40 kilograms (about 88 pounds) and be deemed at high risk for progressing to severe COVID-19 and/or hospitalization. That high-risk category includes adults who are ages 65 or older, or who have chronic medical conditions.
Mother putting mask on daughter

High Genomic Variation Observed in Pediatric COVID-19 Cases

A study carried out by the Children's Hospital Los Angeles shows a high prevalence of the recent D614G variant and other mutations in children infected with SARS-CoV-2, as well as a high level of the 20C clade in severe cases.
Human Respiratory System Lungs Anatomy

Gut Microbiome Potentially Linked to COPD Development Say Australian Researchers

The research suggested that the altered gut microbiome found in COPD patients could also support the gut as a potential target for new treatments.
Asian doctor in PPE medical suit with an injection vaccine and infusion drip for covid-19 or corona virus patient

Pfizer, BioNTech Apply for COVID-19 Vaccine Emergency Use Authorization

The companies said final efficacy data announced earlier this week showing BNT162b2 to be 95% effective in Phase III trial in participants without prior SARS-CoV-2 infection will be presented in support of the application, along with positive safety data.
Microbiotica will use its precision metagenomics microbiome platform in an up-to-$534 million-plus partnership with Genentech

Specific Gut Microbes that Trigger Immune Response to Viral Infections Identified

Low-level interferon signaling that offers antiviral protection in the absence of active infection is present in all humans shortly after birth, but where and how this signaling occurs has remained unclear. The newly reported work offers up an explanation for this phenomenon.
Brain cancer, artwork

U.K. Researchers Develop Method to Predict Medulloblastoma Relapse in Children

The research suggests the nature and outcome of medulloblastoma relapse are biology and therapy dependent, providing translational opportunities for improved disease management through ongoing surveillance, prognostication, and risk-stratified selection of second-line treatments.
Breast cancer cells, SEM

Proteogenomic Approach Could Help Tailor Breast Cancer Treatment

Using a combination of proteomic analyses and DNA and RNA sequencing to profile breast cancer tumors could lead to more effective, tailored treatment, suggests research from the Broad Institute and Baylor College of Medicine.
neurons

Cell Metabolism a Stumbling Block to Neuronal Reprogramming

By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming process, the researchers achieved a four times higher conversion rate and simultaneously increased the speed of reprogramming.
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