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Coronavirus, virus, flu, bacteria close-up. Abstract 3D rendered illustration

Intestinal Organoids Developed to Test New Drugs for COVID-19

SARS-CoV-2 affects many parts of the body. Although the primary manifestations of COVID-19 involve the respiratory system, gastrointestinal effects may play a critical role in both disease severity and transmission.
Illumina’s Extended RAS Panel is designed for use with the company’s MiSeqDx® System to help clinicians identify mCRC patients eligible for treatment with Amgen’s marketed drug Vectibix® (panitumumab). [© adrenalinapura / Fotolia]

WRN May Be Key to Overcoming Colorectal Cancer Drug Resistance

The study from researchers Wellcome Sanger Institute, in collaboration with the Candiolo Cancer Institute in Italy and the Netherlands Cancer Institute, showed for the first time that cancer cells resistant to existing treatments, including chemotherapy, targeted therapies or immunotherapies, require WRN for survival.

Risk of Lung Cancer Linked to Specific Variants

The researchers identified 25 new rare pathogenic variants associated with lung cancer susceptibility and validated five of those variants. Of those five, two variants involved genes with known connections to lung cancer risk, ATM and MPZL2. Three variants involved novel lung cancer susceptibility genes, POMC, STAU2 and MLNR.
Coronavirus infection of lungs, conceptual illustration

Nebulizer Can Deliver CRISPR-Based Treatment Targeting COVID-19 and Influenza

The researchers used mRNA technology to code for Cas13a, which destroys parts of the RNA genetic code that viruses use to replicate in cells in the lungs. Using a guide strand, researchers can provide a map that basically tells the Cas13a protein where to attach to the viruses’ RNA and begin to destroy it.
Gut-brain connection or gut brain axis. Concept art showing a connection from the gut to the brain. 3d illustration.

Gut Microbes That Influence Neurological Disorders May Inspire New Therapies

Researchers at the Baylor College of Medicine report that they have found that microbes in the gut may contribute to certain symptoms associated with complex neurological disorders, which also suggests that microbe-inspired therapies may one day help to treat them.
DNA strand

Emory Study Identifies Genes and Proteins Linked to Depression

A new approach developed at Emory University School of Medicine combines genome-wide association study data with human brain proteomic data and has identified 19 genes and 25 brain proteins that could cause depression.
A wristwatch-like device measures cytokine levels in passive sweat

Sweat Sensor Could Predict Cytokine Storm in COVID-19 Patients

A new sweat sensor can detect seven inflammatory proteins seen at high levels in patients experiencing the kind of extreme immune reaction seen in COVID-19 and in some flu patients, which researchers hope will speed up treatment.

Machine Learning Method Predicts New Cancer Genes

Known as Explainable Multi-Omics Graph Integration (EMOGI), the machine learning method predicted 165 new cancer genes by combining multiomics pan-cancer data—such as mutations, copy number changes, DNA methylation and gene expression—together with protein–protein interaction (PPI) networks.
Biodesix has expanded its lung disease test franchise by acquiring Intagrated Diagnostics (Indi)

New Genetic Markers of Lung Cancer Could Lead to More Personalized Treatments

The researchers found that mutations in KMT2C and KMT2D make non-small cell lung cancer more sensitive to Poly (ADP-ribose) polymerase (PARP) inhibitors, which are already approved for treating prostate, pancreatic, ovarian, and breast cancer patients.
Pancreatic cancer, malignant tumor of pancreas

New Biomarker of Pancreatic Cancer May Predict Benefit of Tumor-Penetrating Peptide

According to the new study, the tumor-penetrating peptide known as iRGD appears to enhance the effects of chemotherapy, reducing metastasis, and increasing survival, to a degree determined by levels of β5 integrin. Essentially, β5 integrin gives chemotherapeutic agents the opportunity to destroy the tumor from within.
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