The meta-analysis, believed to be the largest of its type, reviewed six earlier DNA methylation studies of AD, which represented brain tissue studies of 1,453 individuals.
The researchers examined the proposed link between peroxisome proliferator-activated receptor (PPAR) and how it promotes regeneration and tumorigenesis by enhancing intestinal stem cell numbers, proliferation, and function.
In the three months since J&J’s COVID-19 vaccine received emergency use authorization from the FDA, more than 10 million Americans have received the vaccine, according to the Centers for Disease Control and Prevention.
While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
Inhibition of the NAMPT enzyme pushes triple negative breast cancer cells towards apoptosis and adding compounds that block anti-apoptotic proteins ensures cancer cell death, presenting a new treatment opportunity for these patients.
Research shows that abnormal gene expression changes can occur before islet autoimmunity or type 1 diabetes is present in susceptible children, which could help predict who is most likely to progress to full-blown diabetes.
To explore the potential role of SORBS2 in congenital heart disease, researchers suppressed the gene in developing human heart cells grown in the laboratory. This led to the development of abnormally shaped heart cells and interfered with the ability of cardiac muscle cells to undergo necessary changes in gene expression.
Poverty, poor sanitation, changing agricultural practices and overuse of antibiotics in people and livestock have turned many developing regions into hot spots for diseases spread by bacteria, including infections that are increasingly resistant to a range of antibiotic drug treatments.
Researchers at the University of Chicago show that replacing just one species of a microbe—Bacteroides sp. CL1-UC (Bc)—to the gut microbiome at a specific developmental phase of the disease can prevent antibiotic-induced colitis in a mouse model of the condition.
A recent study by an international team of researchers has found that T cells need to recognize pathogens in a particular orientation in order to receive a strong activating signal.