Former Foundation Medicine Execs Join Hopkins Kimmel Directors, VCs in New Company

Steven Kafka, Ph.D., the former president and chief operating officer of Foundation Medicine who left the company last year, has joined with former colleagues...
Metastasis Infection

Triple Negative Breast Cancers Activate Resistance Pathway to Evade Chemotherapy

Triple-negative breast cancers (TNBCs) are particularly aggressive, metastatic and resistant to chemotherapy treatments.  Researchers at the University of Texas MD Anderson Cancer Center have...
CRISPR technology

Top 600 Cancer Drug Targets Ranked Using CRISPR

Researchers from the Wellcome Sanger Institute, GlaxoSmithKline, EMBL-EBI, and Open Targets conducted one of the largest CRISPR screens of cancer genes to date.
Microscopic image of mitochondrial stained pancreatic cancer cells

Single Gene Deletion Halts Pancreatic Cancer in Mice

The deletion of the ataxia-telangiectasia group D-complementing (Atdc) gene, whose human homolog is up-regulated in the majority of pancreatic cancer cases, completely prevents the development of tumors in mice.

Exclusive: A Conversation with David Bentley, VP and Chief Scientist, Illumina

From Guy's Hospital in London and the Sanger Centre during the Human Genome Project to one of the first to join early sequencing company Solexa and its subsequent acquisition by Illumina, David Bentley has seen clinical genomics come full circle.
Adding blood-based liquid biopsy testing nearly doubled the number of mutations detected in non-small cell lung cancer (NSCLC) compared to solid tissue testing alone

Liquid Biopsies Provide Precision Approach to Ovarian Cancer Treatment

Scientists based at the University of Helsinki reported they were able to use the circulating tumor DNA shed by ovarian tumors to identify clinically actionable mutations and provide targeted treatments to patients.

Five-Year Super Successes in Genomics and Precision Medicine

Multidimensional, computationally rich approaches represent the next wave of innovation, taking personalized medicine to the next level, while demanding more of practitioners, who in...
Source: Martin Barraud/Getty Images

10 Countries in 100K Genome Club

These ten governments have committed funding for projects that will sequence a minimum of 100,000 citizens to spur genomic medicine
Clinician Offering Drugs Based On DNA Profiling

FDA Sends Warning Letter to Inova Over Pharmacogenomics Test

The agency said it is unaware of data establishing that Inova’s tests helps patients or clinicians make appropriate treatment decisions for the listed drugs.
Whole exome sequencing is becoming more available to patients and will help them distill the sequencing data to candidate genes and link them with therapies. [NCI]

Cancer Combination Therapies Tailored to Individuals Show Improved Outcomes

Patients with therapy-resistant cancers show improved outcomes if their treatments are personalized according to the molecular profile of their cancer, according to a new...
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