Body with stomach tumor

FDA Approves First Immunotherapy for Initial Treatment of Gastric Cancer

The PD-1 checkpoint inhibitor Opdivo (nivolumab) has been approved by the FDA as an initial treatment for advanced gastric cancer, adding to its approvals as a treatment for melanoma and a number of other cancers.
A wristwatch-like device measures cytokine levels in passive sweat

Sweat Sensor Could Predict Cytokine Storm in COVID-19 Patients

A new sweat sensor can detect seven inflammatory proteins seen at high levels in patients experiencing the kind of extreme immune reaction seen in COVID-19 and in some flu patients, which researchers hope will speed up treatment.
Biodesix has expanded its lung disease test franchise by acquiring Intagrated Diagnostics (Indi)

New Genetic Markers of Lung Cancer Could Lead to More Personalized Treatments

The researchers found that mutations in KMT2C and KMT2D make non-small cell lung cancer more sensitive to Poly (ADP-ribose) polymerase (PARP) inhibitors, which are already approved for treating prostate, pancreatic, ovarian, and breast cancer patients.

Risk of Lung Cancer Linked to Specific Variants

The researchers identified 25 new rare pathogenic variants associated with lung cancer susceptibility and validated five of those variants. Of those five, two variants involved genes with known connections to lung cancer risk, ATM and MPZL2. Three variants involved novel lung cancer susceptibility genes, POMC, STAU2 and MLNR.
Coronavirus infection of lungs, conceptual illustration

Nebulizer Can Deliver CRISPR-Based Treatment Targeting COVID-19 and Influenza

The researchers used mRNA technology to code for Cas13a, which destroys parts of the RNA genetic code that viruses use to replicate in cells in the lungs. Using a guide strand, researchers can provide a map that basically tells the Cas13a protein where to attach to the viruses’ RNA and begin to destroy it.
Gut-brain connection or gut brain axis. Concept art showing a connection from the gut to the brain. 3d illustration.

Gut Microbes That Influence Neurological Disorders May Inspire New Therapies

Researchers at the Baylor College of Medicine report that they have found that microbes in the gut may contribute to certain symptoms associated with complex neurological disorders, which also suggests that microbe-inspired therapies may one day help to treat them.
Coronavirus, virus, flu, bacteria close-up. Abstract 3D rendered illustration

Intestinal Organoids Developed to Test New Drugs for COVID-19

SARS-CoV-2 affects many parts of the body. Although the primary manifestations of COVID-19 involve the respiratory system, gastrointestinal effects may play a critical role in both disease severity and transmission.
Alzheimer's disease: the amyloid-beta peptide accumulates to amyloid fibrils that build up dense amyloid plaques.

Increasing ABCC1 Gene Expression Could Help Prevent Alzheimer’s Disease

The ABCC1 protein has the ability to break down amyloid plaques in Alzheimer’s disease and researchers show in a new study that increasing expression of this gene may even prevent the neurodegenerative disease from developing in the first place.
Pancreatic cancer, malignant tumor of pancreas

Metabolic Profiling for Pancreatic Cancer Predicts Patient Outcomes

A team of researchers from Centre de Recherche en Cancerologie de Marseille (CRCM), INSERM in France have developed a new method for capturing the metabolic signature of pancreatic ductal adenocarcinoma to predict clinical outcomes.
Scientists conducting the process of Polymerase chain reaction (PCR) to amplify DNA by using a thermocycler to create samples

Direct RNA Amplification Reagents

The new automation friendly reagents allow laboratories testing for COVID-19 have a tool that allows them to skip the RNA extraction step of the many testing workflows and move directly to PCR amplification.
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