Autism spectrum disorder, conceptual illustration

iPSYCH Project Finds Shared Mutations in Autism and ADHD

One of the most commonly shared types of mutations were those affecting the microtubule-associated protein 1A gene (MAP1A), which increases risk of developing one of these conditions by more than 15 times.
The combination of Bristol-Myers Squibb (BMS)'s marketed cancer immunotherapies Opdivo (nivolumab) plus a low dose of Yervoy (ipilimumab) showed durable clinical benefit in a Phase II trial as a first-line treatment in patients with microsatellite instability-high (MSI-H) or DNA mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC)

New Link Discovered Between Cells That Burn Fat and Colon Cancer

Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota. This new study suggests a novel connection between HNF4A and HNF4G genes, diet, and cancer.
DNA research concept DNA barcodes for biomedical research  mitochondrial DNA  Prostate cancer DNA test

Scientists Discover New Role For ‘Junk’ DNA in Cancer Development

The mechanism identified suggests that when an oncogene is activated and begins to replicate itself in an uncontrolled fashion, creating multiple copies of itself within the genome (and beginning the process of turning a normal cell into a cancerous one), non-coding DNA material is included in the replication sequence.
Colon cancer, light micrograph

Dx Identifies Epigenetic Changes Linked to Microbiota Imbalance that Promotes Colorectal Cancer

The scientists showed that transplanting fecal microbiota from patients with colon cancer into mice caused lesions and epigenetic changes that were characteristic of the development of a malignant tumor.
Parkinson's disease, substantia nigra, Lewy bodies

Mount Sinai Team Finds New Molecular Drivers of Parkinson’s

Scientists at Mount Sinai’s Icahn School of Medicine have uncovered new molecular drivers of Parkinson’s disease using multiscale gene network analysis.

Personalis, Merck KGaA Launch Cancer Biomarker Collaboration

Personalis said it will partner with Merck KGaA, Darmstadt, Germany, to identify and develop novel clinical biomarkers for cancer therapies, through a collaboration whose...
Bladder cancer, light micrograph

New Anti-PD-L1 Study Findings Support Immunotherapy for Bladder Cancer

This single-arm Phase II study investigating two cycles of atezolizumab achieved the primary efficacy endpoint, showing a pathological complete response rate of 31%.
Biocept intends to become Thermo Fisher Scientific’s “Center of Excellence” for oncology-focused liquid biopsy efforts as part of a commercial collaboration by the companies. [© AlexRaths/iStock]

Lexent, Illumina Enter Partnership for Cancer Monitoring Liquid Biopsy Kits

Confera Dx is currently in development with the intention to be made available next year as a laboratory-developed test performed by Lexent in a CLIA-certified laboratory with the intention of developing a distributed in vitro diagnostic at a later date. 
Owlstone Medical will partner with Renji Hospital in Shanghai to conduct a clinical trial assessing the company's Breath Biopsy diagnostic breathalyzer platform in early detection of lung cancer

Owlstone Medical, Thermo Fisher Forge Breath Biopsy Technology Collaboration

The collaboration will integrate Thermo Fisher’s Orbitrap gas chromatography mass spectrometry (GC-MS) instrumentation into Owlstone’s breath biopsy platform to conduct metabolomics studies for unique biomarkers.

PredictImmune Partners with Foundation on Study to Validate IBD Test

The test stratifies patients based on their risk of subsequently experiencing a severe disease course, which is characterized by the requirement for multiple escalations in treatment due to frequently relapsing or chronically active disease.
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