Colon cancer, light micrograph

ctDNA Methylation Profiles Power Effective Colorectal Cancer Diagnosis, Prognosis, and Screening

ctDNA methylation profiling provides several advantages over somatic mutation analysis for cancer detection, including higher clinical sensitivity and dynamic range, and multiple detectable methylation target regions.
Human microbiome, conceptual illustration

UC Irvine Pair Launch the Microbiome Centers Consortium

The goal is to help train researchers at mid-career and beyond on the diverse range of microbiome science techniques, including study and experiment design, DNA sequencing, data analysis, and metabolomics—the large-scale investigation of metabolites.

Guardant360 Gets Expanded LCD for Broad Swath of Solid Tumor Cancers

The coverage decision from Palmetto GBA includes all fee-for-service Medicare patients with advanced cancers who meet its clinical criteria for genomic profiling to help select the most appropriate treatment, but don’t have tissue samples for molecular profiling.
Light micrograph of metastases in breast tissue

Triple Negative Breast Cancer Recurrence Prediction Method Developed

Women whose plasma contained circulating tumor DNA had only a 56% chance of being cancer-free two years following chemotherapy and surgery, while those without it had an 81% chance the cancer would not return in the same time span.
Cambridge Epigenetix has launched a discovery and development program for a test to detect colorectal and other cancers

Only 40% of Metastatic Colon Cancer Patients Get Guideline-Recommended Genomic Testing

This study also showed that using a comprehensive panel, as opposed to single-gene testing, could possibly result in a 50% increase in guideline-recommended testing rates.

DNAnexus Wins Five-Year, $20M Contract to Power precisionFDA Platform

Enhancements include upgrading the platform’s sponsor-reviewer interaction, adding support for multi-omics, and offering a library of analytical, statistical, and machine learning applications that are both accessible to reviewers and sufficiently powerful for bioinformaticians.

Blood Test that Measures Expression of 5,000 Proteins Shows Potential as Disease Screening Tool

Researchers scanned 5,000 proteins in single blood plasma samples taken from 16,894 participants to simultaneously capture the individualized imprints of current health status, and incident risk of cardiometabolic diseases such as diabetes, coronary heart disease, stroke,and heart failure.

Hibernation Provides Genetic Clues to Understanding Obesity

Researchers compared the genomes of four hibernating mammals with humans to search for genetic links modulating hibernation, obesity and metabolic disorders and identified 364 potential genetic elements they believe could have a role in regulating hibernation and obesity.
Autism spectrum disorder, conceptual illustration

iPSYCH Project Finds Shared Mutations in Autism and ADHD

One of the most commonly shared types of mutations were those affecting the microtubule-associated protein 1A gene (MAP1A), which increases risk of developing one of these conditions by more than 15 times.
The combination of Bristol-Myers Squibb (BMS)'s marketed cancer immunotherapies Opdivo (nivolumab) plus a low dose of Yervoy (ipilimumab) showed durable clinical benefit in a Phase II trial as a first-line treatment in patients with microsatellite instability-high (MSI-H) or DNA mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC)

New Link Discovered Between Cells That Burn Fat and Colon Cancer

Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota. This new study suggests a novel connection between HNF4A and HNF4G genes, diet, and cancer.
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