One of the most commonly shared types of mutations were those affecting the microtubule-associated protein 1A gene (MAP1A), which increases risk of developing one of these conditions by more than 15 times.
Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota. This new study suggests a novel connection between HNF4A and HNF4G genes, diet, and cancer.
The mechanism identified suggests that when an oncogene is activated and begins to replicate itself in an uncontrolled fashion, creating multiple copies of itself within the genome (and beginning the process of turning a normal cell into a cancerous one), non-coding DNA material is included in the replication sequence.
The scientists showed that transplanting fecal microbiota from patients with colon cancer into mice caused lesions and epigenetic changes that were characteristic of the development of a malignant tumor.
Scientists at Mount Sinai’s Icahn School of Medicine have uncovered new molecular drivers of Parkinson’s disease using multiscale gene network analysis.
Personalis said it will partner with Merck KGaA, Darmstadt, Germany, to identify and develop novel clinical biomarkers for cancer therapies, through a collaboration whose...
This single-arm Phase II study investigating two cycles of atezolizumab achieved the primary efficacy endpoint, showing a pathological complete response rate of 31%.
Confera Dx is currently in development with the intention to be made available next year as a laboratory-developed test performed by Lexent in a CLIA-certified laboratory with the intention of developing a distributed in vitro diagnostic at a later date.
The collaboration will integrate Thermo Fisher’s Orbitrap gas chromatography mass spectrometry (GC-MS) instrumentation into Owlstone’s breath biopsy platform to conduct metabolomics studies for unique biomarkers.
The test stratifies patients based on their risk of subsequently experiencing a severe disease course, which is characterized by the requirement for multiple escalations in treatment due to frequently relapsing or chronically active disease.