Sponsored: Making NGS Actionable—Moving Oncology Beyond ‘One Mutation-One Drug’

While most NGS providers limit their annotated reports to one mutation-one drug associations that address targeted therapeutics, Cellworks’ biosimulation platform permits an assessment of all cancer therapies, including radiation, chemotherapy, and immunotherapy.
Woman injecting insulin, daily diabetes care during COVID-19

Early Changes in Gene Expression Observed Pre-Diagnosis in Type 1 Diabetes

Research shows that abnormal gene expression changes can occur before islet autoimmunity or type 1 diabetes is present in susceptible children, which could help predict who is most likely to progress to full-blown diabetes.
NGS technology has enabled researchers to epidemiologically analyze DNA sequences by quickly deciphering mass quantities of genetic information in a short amount of time. [Heart illustration: iStock/SvetaP DNA double helix: iStock/Kagenmi]

Study Supports Link Between SORBS2 and Congenital Heart Disease

To explore the potential role of SORBS2 in congenital heart disease, researchers suppressed the gene in developing human heart cells grown in the laboratory. This led to the development of abnormally shaped heart cells and interfered with the ability of cardiac muscle cells to undergo necessary changes in gene expression.
Human Kidney Cancer Anatomy

Single-cell RNA Sequencing Reveals Kidney Cancer Cellular Origins

Along with identifying these putative cell of origin for a variety of RCCs, the analysis also revealed pathways and interactions within the tumor microenvironment that predicted whether the tumor would respond to immunotherapy.
Scientists conducting the process of Polymerase chain reaction (PCR) to amplify DNA by using a thermocycler to create samples

RADICA Technique Speeds Up Molecular Detection of COVID-19 While Maintaining Accuracy

A technique combining digital PCR and CRISPR based detection with a LAMP-style simple amplification detects SARS-CoV-2 and other viruses quickly and specifically without the time consuming and costly need for thermal cycling of RT-PCR.
Fireworks in Brain

Study Affirms Value of Neurofilament Light as Neurodegeneration Blood Biomarker

A single biomarker—neurofilament light chain—can indicate the presence of underlying neurodegeneration with excellent accuracy across several different disorders, according to new research.
Lung Cancer

KRAS Lung Cancer Drug Reaches Clinic via Accelerated FDA Approval

Amgen's Lumakras, a small molecule just approved for clinical use by the FDA, becomes the first targeted therapy for lung cancer patients with KRAS mutations, an urgently needed option for patients with limited therapeutic options.
corona virus 1

COVID-19 Antiviral Candidate Targeting RNA Replicase Developed

U.S. researchers have developed an antiviral candidate drug targeting iron-sulfur clusters needed for SARS-CoV-2 RNA replicase to function properly and for the virus to reproduce successfully.

Helix Raises $50M Series C Financing toward Platform, COVID-19 Testing, Viral Surveillance

Helix has developed an end-to-end genomics platform designed to advance genomic research and accelerate the integration of genomic data into clinical care through its unique Sequence Once, Query Often model.
Students studying in the classroom including a disability boy

Non-Coding Gene Variants Linked with Developmental Disorders in Children

The findings are part of the U.K. Deciphering Developmental Disorders (DDD) study, which recruited children with undiagnosed developmental disorders between 2010-2015 to see if new genetic technologies can help doctors understand why patients get developmental disorders.

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