U.K. Researchers Develop Method to Predict Medulloblastoma Relapse in Children
The research suggests the nature and outcome of medulloblastoma relapse are biology and therapy dependent, providing translational opportunities for improved disease management through ongoing surveillance, prognostication, and risk-stratified selection of second-line treatments.
Proteogenomic Approach Could Help Tailor Breast Cancer Treatment
Using a combination of proteomic analyses and DNA and RNA sequencing to profile breast cancer tumors could lead to more effective, tailored treatment, suggests research from the Broad Institute and Baylor College of Medicine.
Cell Metabolism a Stumbling Block to Neuronal Reprogramming
By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming process, the researchers achieved a four times higher conversion rate and simultaneously increased the speed of reprogramming.
Combination of Imaging and Machine Learning Can Predict Melanoma Prognosis
An artificial neural network can accurately predict the prognosis of melanoma patients based on pre-treatment histology images, shows research led by the NYU Grossman School of Medicine.
New Technique Provides Live View of Viral Replication
Researchers have developed an advanced technique, named VIRIM (virus infection real-time imaging), that makes it possible for the entire course of a virus infection to be visualized in the lab with great precision.
New Drug Screening Approach Points to Personalized Medulloblastoma Treatments
The researchers discovered several drugs stopped growth of cells from the most aggressive medulloblastoma subtype: actinomycin D, oleandrin, gambogic acid, idarubicin, and bortezomib. In a study of live mice with the patient-derived xenograft cells, actinomycin D extended their survival.
Brain Injury from Stroke Assessed by Blood-Based Biomarker
The researchers examined correlations between levels of the neurofilament light protein and the degree of brain injury, in addition to neurological, functional, or cognitive status of patients at the time their blood was collected.
New Gene Therapy Approach Prevents Toxicity Tied to AAV Vectors
An altered transgene lowered transgene expression in the dorsal root ganglia by more than 80% and reduced toxicity in primates—considered a major hurdle to gene therapy for central nervous system conditions.
New Role for Gene Critical in Heart Development Discovered
The gene CRELD1, known to play an important role in the development of the heart in the embryo, has now been shown to be an important gatekeeper of immune system homeostasis, according to researchers at the University of Bonn in Germany.
Uninfected Children More Likely to Have Preexisting SARS-CoV-2 Antibodies than Adults
In cell culture experiments, sera from both older and younger uninfected individuals with cross-reactive antibodies showed the ability to neutralize SARS-CoV-2 and SARS-CoV-2 S pseudotypes, whereas sera from uninfected patients lacking cross-reactive antibodies exhibited no such neutralizing activity.
