Brain cancer, artwork

U.K. Researchers Develop Method to Predict Medulloblastoma Relapse in Children

The research suggests the nature and outcome of medulloblastoma relapse are biology and therapy dependent, providing translational opportunities for improved disease management through ongoing surveillance, prognostication, and risk-stratified selection of second-line treatments.
Breast cancer cells, SEM

Proteogenomic Approach Could Help Tailor Breast Cancer Treatment

Using a combination of proteomic analyses and DNA and RNA sequencing to profile breast cancer tumors could lead to more effective, tailored treatment, suggests research from the Broad Institute and Baylor College of Medicine.

Cell Metabolism a Stumbling Block to Neuronal Reprogramming

By expressing neuron-enriched mitochondrial proteins at an early stage of the direct reprogramming process, the researchers achieved a four times higher conversion rate and simultaneously increased the speed of reprogramming.

Combination of Imaging and Machine Learning Can Predict Melanoma Prognosis

An artificial neural network can accurately predict the prognosis of melanoma patients based on pre-treatment histology images, shows research led by the NYU Grossman School of Medicine.
influenza Virus Replication

New Technique Provides Live View of Viral Replication

Researchers have developed an advanced technique, named VIRIM (virus infection real-time imaging), that makes it possible for the entire course of a virus infection to be visualized in the lab with great precision.

New Drug Screening Approach Points to Personalized Medulloblastoma Treatments

The researchers discovered several drugs stopped growth of cells from the most aggressive medulloblastoma subtype: actinomycin D, oleandrin, gambogic acid, idarubicin, and bortezomib. In a study of live mice with the patient-derived xenograft cells, actinomycin D extended their survival.
Stroke, illustration

Brain Injury from Stroke Assessed by Blood-Based Biomarker

The researchers examined correlations between levels of the neurofilament light protein and the degree of brain injury, in addition to neurological, functional, or cognitive status of patients at the time their blood was collected.
3D Rendered Illustration, visualisation of neurons firing neurotransmitters in the synaptic gap

New Gene Therapy Approach Prevents Toxicity Tied to AAV Vectors

An altered transgene lowered transgene expression in the dorsal root ganglia by more than 80% and reduced toxicity in primates—considered a major hurdle to gene therapy for central nervous system conditions. 
Monocyte immune system defense cells, 3D Rendering

New Role for Gene Critical in Heart Development Discovered

The gene CRELD1, known to play an important role in the development of the heart in the embryo, has now been shown to be an important gatekeeper of immune system homeostasis, according to researchers at the University of Bonn in Germany.
Antibody proteins attacking coronavirus, illustration

Uninfected Children More Likely to Have Preexisting SARS-CoV-2 Antibodies than Adults

In cell culture experiments, sera from both older and younger uninfected individuals with cross-reactive antibodies showed the ability to neutralize SARS-CoV-2 and SARS-CoV-2 S pseudotypes, whereas sera from uninfected patients lacking cross-reactive antibodies exhibited no such neutralizing activity.
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