Antiviral T Cells Prove Useful for Debilitating Stem Cell Transplant Side Effect
BK virus-associated hemorrhagic cystitis is a painful complication and common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The researchers hope this new approach provides an “off-the-shelf” treatment for this condition.
Patient in Adverum Gene Therapy Trial Loses Sight in One Eye
The company announced that the patient developed hypotony with panuveitis and loss of vision in the treated eye 30 weeks after the patient was randomized to receive a single intravitreal injection of a high dose of ADVM-022, its candidate to treat diabetic macular edema.
Oncogene Linked to Worsening of Blood Vessel Malformations in Brain
Research from the University of Pennsylvania and Duke University shows an acquired mutation in the cancer-causing gene PIK3CA can trigger uncontrolled growth in cerebral cavernous malformations often leading to strokes or seizures in those affected.
Fragile X Treatment Shows Promise in Phase II Trial
The first in a new drug class of phosphodiesterase‐4D allosteric inhibitors developed by Tetra Therapeutics is well tolerated and helps improve cognition in people with fragile X syndrome, show results from a Phase II trial.
Sanger Institute Improves NanoSeq Method to Detect New Mutations in Non-Dividing Cells
NanoSeq, a new and carefully refined form of duplex sequencing developed at the Wellcome Sanger Institute, is highly accurate and can detect single-cell mutations, which could allow early detection of diseases such as cancer.
![Geisinger Health will begin offering DNA sequencing to patients as part of its routine clinical care. [iStock/Mark Bowden]](https://www.clinicalomics.com/wp-content/uploads/2019/01/1648-218x150.jpeg "Mismatch Repair Algorithm Could Help Personalize Cancer Care")
Mismatch Repair Algorithm Could Help Personalize Cancer Care
An algorithm called MMRDetect, designed by University of Cambridge researchers, can detect tumors that have mismatch repair mutations that should make them more vulnerable to treatment with immune checkpoint inhibitors.
Stem Cell Therapy to Repair Stroke and Dementia Damage Shows Early Promise
An experimental glial stem cell therapy, designed by UCLA researchers, can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia.
Artificial Intelligence Can Help Improve Bowel Cancer Treatment
High levels of two proteins linked to EGFR, amphiregulin and epiregulin, are linked to better outcomes in patients treated with the monoclonal antibody panitumumab, shows a new study using artificial intelligence to aid data analysis.
New Computational Method Improves Genetic Disease Risk Prediction
Researchers selected several hundred thousand genetic markers and, using their statistical model, linked the composition of these markers to the onset of high blood pressure, heart disease, or type 2 diabetes in the patients in the database.
Computational Tool Can Map Gene Expression in Space
Swiss scientists have developed a computational algorithm known as ‘Tomographer’ that can visualize and map gene expression in organs using tissue measurement and messenger RNA data.
