Scientists conducting the process of Polymerase chain reaction (PCR) to amplify DNA by using a thermocycler to create samples

RADICA Technique Speeds Up Molecular Detection of COVID-19 While Maintaining Accuracy

A technique combining digital PCR and CRISPR based detection with a LAMP-style simple amplification detects SARS-CoV-2 and other viruses quickly and specifically without the time consuming and costly need for thermal cycling of RT-PCR.
Sickle cell anemia

Base Editor Effectively Treats Sickle-Cell Disease in Mice

Researchers have corrected the sickle cell disease-causing variant in mice and in a human cell line using a base editor without requiring double-stranded DNA breaks or inserting new segments of DNA into the genome.
Lung Cancer

KRAS Lung Cancer Drug Reaches Clinic via Accelerated FDA Approval

Amgen's Lumakras, a small molecule just approved for clinical use by the FDA, becomes the first targeted therapy for lung cancer patients with KRAS mutations, an urgently needed option for patients with limited therapeutic options.
Neurons sending pulsating electric impulses and communicating with each other. Concept For Neurological Diseases, Tumors And Brain Surgery

Next Steps for Huntington’s Therapeutics Field After Roche, Wave Failures

Roche and Wave's Huntington's disease ASO trials failed earlier this year, but researchers in the field remain positive that a more effective therapy will be developed in the not too distant future.
Glioblastoma brain cancer, CT scan

Targeting Specific Enzyme May Improve Glioblastoma Therapy

After analyzing 330 metabolism genes in a pre-clinical model of glioblastoma, MD Anderson researchers discovered that several enzymes involved in fatty acid metabolism were important for glioblastoma cells.
3d illustration of a cancer cell in the process of mitosis

Chemical Changes Enhance siRNA-Based Cancer Drug Delivery

To harness siRNA’s gene silencing capabilities, scientists must get it into the appropriate cells, which requires attaching it to a larger molecule to protect it during delivery. Peptide carriers are an attractive tool for delivering siRNA, because they are affordable and easy to modify.
female scientist with a slide with a breast tumour

Quest to Partner with Paige.ai To Develop AI-Driven Digital Pathology Cancer Diagnostics

Memorial Sloan Kettering spin-out Paige will partner with Quest Diagnostics to develop precise AI-driven cancer assessment tools to speed up and improve diagnosis for patients with a range of solid tumors.
Antibodies responding to coronavirus particle, illustration

Antibody-Producing Cells Last at Least One Year After COVID-19 Infection

A new study finds that nearly a year after recovering from COVID-19, the body’s bone marrow plasma cells still make active antibodies against the virus. The findings appear to suggest that antibody production does not wane over time to the point of offering no protection.
Antibody proteins attacking coronavirus, illustration

Structural Details of How SARS-CoV-2 Variants Escape Immune Response Detailed in New Study

The researchers used structural biology to map, at atomic scale, how certain classes of neutralizing antibodies bind to the original pandemic strain of SARS-CoV-2, the virus that causes COVID-19.
Female doctor using otoscope on child

OSU Researchers Make Advances in Developing Gene Therapy to Allow the Deaf to Hear

The progress was made in the study of a gene responsible for an inner-ear protein, otoferlin. Mutations in otoferlin are linked to severe congenital hearing loss, a common type of deafness in which patients can hear almost nothing.

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