Cloned Faces with digital background

Whole-Genome Sequencing Comes of Age in Clinical Care

In this Clinical OMICs KEYNOTE webinar, sponsored by Illumina, we are delighted to host two true pioneers of clinical genome sequencing, bioinformatician Dr. Liz Worthey and geneticist Dr. Howard Jacob, who will reflect on a decade of progress in clinical genome analysis and discuss the future challenges confronting the field.

Thermo Fisher Partners with AstraZeneca, UNMC on Clinical Biomarker Analysis Workflows

The new partnerships are intended to bolster Thermo Fisher's Precision Medicine Science Center's mission of creating standardized workflows with pharma and academic partners, with the goal of enhancing precision medicine by streamlining the transition from biomarker research to clinical implementation.
Human liver

Drug-Induced Liver Injury Predicted by Polygenic Risk Score

By combining available genome-wide association study data and applying mathematical weighting methods, the team found a PRS formula that appears to predict which patients may develop DILI as a result of taking different drugs.
PD-1 is a checkpoint to slow down T-cells. PD-1  (red) extends from the surface of a T-cell interacting with the ligand protein PD-L1 (yellow) from an antigen presenting cell.

Immuno-Oncology Drug Response Predicted via New Imaging Method

Using induced fluorescence resonance energy transfer (iFRET), the researchers directly assessed interaction between programmed death ligand-1 (PD-L1) ligand with its receptor programmed death receptor-1 (PD-1), in patients’ tumor samples.
Portrait of woman holding black and white younger photo of herself

Pooled Genome-Wide Data Analysis Finds Link Between Blood Iron Levels and Aging

The study combined genome-wide association summary statistics for heart disease, dementia, and cancers and identified 10 genomic loci that appear to influence all three of those phenotypes.
Glioblastoma brain cancer, CT scan

New Biobank May Inform Targeted Glioblastoma Therapies

It has become evident that GBM tumors contain many genetic aberrations that vary between patients, but there are still few methods to take account of these changes and patients currently receive similar treatments.
investigators discover a rare genetic variant shown to protect people who carry known genetic risk factors for Alzheimer's disease

New Research Shows Why ApoE4 Increases Alzheimer’s Disease Risk

The researchers found that the lipid composition was healthy in the brain of mice with ApoE3 with sufficient amounts of unsaturated fatty acids and endocannabinoids. But when compared to the brain cells of E3, the E4 mice did not receive enough lipids.
Micrograph of myeloma neoplasm from bone marrow biopsy

GNS Healthcare, Partners Identify Transcription Factor Linked to Multiple Myeloma

GNS Healthcare and partners said the identification of PHF19 could lead to improvements in how diagnostics developers target the transcription factor through single gene tests—as well as how researchers design clinical trials, and how oncologists make decisions on treating patients with newly diagnosed multiple myeloma.
HLI and Merck KGaA will focus on identifying biomarkers in patients with locally advanced or metastatic NRAS mutated cutaneous melanoma that show a preferential response to Merck’s pimasertib.. [© M&S Fotodesign/Fotolia]

APOE Variant May Protect Against Melanoma Spread

The research showed that both mouse and human carriers of the APOE4 gene variant had less melanoma progression and metastasis compared with those who had the APOE2 gene variant, as well as a better response to cancer immunotherapy.
Senior male smoking cigarette on black background

Smoking May Exacerbate COVID-19 Infection by Increasing ACE2 Expression

Smoking increases the gene expression of ACE2—the protein that binds SARS-CoV-2. The study suggests that prolonged smoking could cause an increase of the ACE2 protein in the lungs, possibly resulting in a higher rate of morbidity in patients.
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