Biomarkers

Sponsor: IlluminaIn this Clinical OMICs KEYNOTE webinar, sponsored by Illumina, we are delighted to host two true pioneers of clinical genome sequencing, bioinformatician Dr. Liz Worthey and geneticist Dr. Howard Jacob, who will reflect on a decade of progress in clinical genome analysis and discuss the future challenges confronting the field.

The new partnerships are intended to bolster Thermo Fisher's Precision Medicine Science Center's mission of creating standardized workflows with pharma and academic partners, with the goal of enhancing precision medicine by streamlining the transition from biomarker research to clinical implementation.

By combining available genome-wide association study data and applying mathematical weighting methods, the team found a PRS formula that appears to predict which patients may develop DILI as a result of taking different drugs.

Using induced fluorescence resonance energy transfer (iFRET), the researchers directly assessed interaction between programmed death ligand-1 (PD-L1) ligand with its receptor programmed death receptor-1 (PD-1), in patients’ tumor samples.

The study combined genome-wide association summary statistics for heart disease, dementia, and cancers and identified 10 genomic loci that appear to influence all three of those phenotypes.

It has become evident that GBM tumors contain many genetic aberrations that vary between patients, but there are still few methods to take account of these changes and patients currently receive similar treatments.

The researchers found that the lipid composition was healthy in the brain of mice with ApoE3 with sufficient amounts of unsaturated fatty acids and endocannabinoids. But when compared to the brain cells of E3, the E4 mice did not receive enough lipids.

GNS Healthcare and partners said the identification of PHF19 could lead to improvements in how diagnostics developers target the transcription factor through single gene tests—as well as how researchers design clinical trials, and how oncologists make decisions on treating patients with newly diagnosed multiple myeloma.

The research showed that both mouse and human carriers of the APOE4 gene variant had less melanoma progression and metastasis compared with those who had the APOE2 gene variant, as well as a better response to cancer immunotherapy.

Smoking increases the gene expression of ACE2—the protein that binds SARS-CoV-2. The study suggests that prolonged smoking could cause an increase of the ACE2 protein in the lungs, possibly resulting in a higher rate of morbidity in patients.