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In this Clinical OMICs KEYNOTE webinar, sponsored by Illumina, we are delighted to host two true pioneers of clinical genome sequencing, bioinformatician Dr. Liz Worthey and geneticist Dr. Howard Jacob, who will reflect on a decade of progress in clinical genome analysis and discuss the future challenges confronting the field.
Coronavirus Covid-19 Vaccine
AstraZeneca and the University of Oxford resumed the clinical study they paused last week after one U.K. participant developed a “potentially unexplained illness,” while Pfizer and BioNTech have requested FDA approval to add 14,000 participants to their late-stage study.
Coronavirus disease of the lungs, conceptual illustration
Neutrophil extracellular traps (NETs) often appeared to almost completely obstruct the small bronchioles and alveoli that mediate gas exchange.
Microscopic image of mitochondrial stained pancreatic cancer cells
As well as finding a number of genetic variants also found in other cancers, the researchers discovered three variants specific to patients with the more aggressive cancer, notably, they also identified an inhibitor that could target one of the genetic mutations specific to adenosquamous pancreatic cancer.
Antibodies responding to covid-19 coronavirus, illustration
There is a need for a quicker and more efficient antibody tests that can detect levels of antibodies against COVID-19, both so that prior infection and levels of immunity can be detected, but also to test plasma being used as a therapy.
The new partnerships are intended to bolster Thermo Fisher's Precision Medicine Science Center's mission of creating standardized workflows with pharma and academic partners, with the goal of enhancing precision medicine by streamlining the transition from biomarker research to clinical implementation.
Seattle Wildlife
By analyzing the genomic sequences of SARS-CoV-2 samples from infected patients in Washington State, research suggests that most early infections derive from a single introduction in late January or early February, sparking rapid community transmission of the virus that went undetected for several weeks.
Acute lymphoblastic leukaemia, illustration
St. Jude researchers showed that an inherited variant of the GATA3 gene is tied to minimal residual disease levels and response to therapy for acute lymphoblastic leukemia.
The ability to generate high-affinity Spike protein binders that block viral interaction with ACE2, but which are highly stable, and small—“to maximize the density of inhibitory domains”—could have multiple advantages over antibodies for direct delivery into the respiratory system.
lymphedema treatment
By screening 543 individuals affected by primary lymphedema, using whole-exome sequencing, mutations in ANGPT2 were discovered in patients from five families; one heterozygous de novo ANGPT2 whole-gene deletion and four heterozygous ANGPT2 missense mutations.
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