Home Blog Page 225
One novel technique for capturing clinically important low-abundance proteins is to create core-shell hydrogel nanoparticles containing high affinity reactive chemical baits for protein and peptide harvesting and concentration. [AlexRaths/iStock Photos]
Many scientists point out that it’s become clear there are no simple universal strategies for the comprehensive analysis of complex proteomes. Although the application of omics technologies to biological samples generates hundreds to thousands of biomarker candidates, a small number actually make it through the pipeline to clinical use, largely due to the incredible mismatch between the large numbers...
The predicted secondary structure of peptide p5+14. The peptide is alpha helical with all the charged lysine residues on one face of the helix. [University of Tennessee]
Researchers are developing a host of new uses for molecular imaging techniques—including magnetic resonance imaging (MRI), positron emission tomography (PET), and single photon emission computed tomography (SPECT)—that are already commonly used in patient care. Once these techniques have picked up new capabilities in the laboratory, they will return to the clinic, where they will likely transform the diagnosis and...
Researchers have found a growing understanding and acceptance by pregnant women of ccfDNA testing. [© igorborodin/ Fotolia]
In October 2011, the Sequenom Center for Molecular Medicine (SCMM) became the first laboratory in the United States to offer next-generation sequencing of circulating cell-free (ccf) DNA testing for Down syndrome (trisomy 21). This commercial launch followed the publication of an external clinical validation study demonstrating that testing could identify 98.6% of fetuses with Down syndrome (209/212) with a...
Source: © Mopic - Fotolia.com
The application of genomics in cancer has led to an improved understanding of the disease. To date, 125 driver genes have been discovered—71 tumor suppressors and 54 oncogenes—that promote tumor growth through 12 cellular signaling pathways.1 These pathways have become the focus of small molecule inhibitor drugs, primarily targeting kinases. While the number of available targeted therapies is limited,...

The twelfth issue of Clinical OMICs is available now! Check it out by clicking on the link below.

Source: © Sebastian Kaulitzki - Fotolia.com
Precision cancer therapy firm Perthera is partnering with the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and the Northwestern Medicine Developmental Therapeutics Institute (NMDTI) to conduct a translational research program aimed at assessing the utility of integrating next-generation sequencing, proteomic, and phospho-proteomic data in oncology developmental therapeutics and clinical practice. Under the alliance, the three organizations plan...
Total Glut4 glucose transporter (left
An exhaustive analysis of fatty acids from a diabetes-protected animal model has revealed a whole new class of molecules. These molecules, dubbed fatty acid hydroxyl fatty acids, or FAHFAs, enhance insulin sensitivity and glucose control. Better yet, they also reduce inflammation. Ordinarily, elevated fatty acids are associated with insulin resistance and glucose intolerance, which in turn are associated with diabetes...
Source: © uwimages - Fotolia.com
Roche has picked up exclusive rights to AbVitro's primer extension-based target enrichment (PETE) technology and associated patent applications AbVitro has filed. The technology, Roche says, will be used to support next-generation sequencing (NGS) directly from blood or other biological samples—something that could be a boon for clinicians. Roche plans to incorporate PETE technology into its Sequencing Unit R&D pipeline to...
As omics technologies continue to migrate toward clinical applications, a market involving prognostic and predictive biomarkers is growing rapidly. This is an important space as it represents the segregation of biomarkers into classes based on their clinical utility. Biomarkers will be fundamental to the success of targeted therapeutics in the future. The implementation of personalized medicine in oncology and beyond requires a precise...
Figure 1. Method of sequencing samples from a JAK2-negative myeloproliferative neoplasm patient
As one of the most prevalent causes of death across the globe, the burden of cancer is still sharply increasing, predominantly due to the aging population. As such, the current focus of many researchers is on how to accurately diagnose and treat various cancer types. However, human cancers usually carry several different genomic variations, such as copy number variations...
Scroll Up