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Autism spectrum disorder, conceptual illustration
One of the most commonly shared types of mutations were those affecting the microtubule-associated protein 1A gene (MAP1A), which increases risk of developing one of these conditions by more than 15 times.
The combination of Bristol-Myers Squibb (BMS)'s marketed cancer immunotherapies Opdivo (nivolumab) plus a low dose of Yervoy (ipilimumab) showed durable clinical benefit in a Phase II trial as a first-line treatment in patients with microsatellite instability-high (MSI-H) or DNA mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC)
Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota. This new study suggests a novel connection between HNF4A and HNF4G genes, diet, and cancer.
Dengue virus, Illustration
The researchers say this approach, which is based on structural DNA nanotechnology, could be effective against many different viruses because like Dengue, all other viruses must first attach to the cell wall to infect their host.
Vantari Genetics and Translational Software® (TSI) said they will support the Banner Alzheimer’s Institute’s (BAI) GeneMatch registry by providing genotype testing
This study used newer sequencing methods in Genome-Wide Associated Studies (GWAS) to provide more complete genetic analysis of neurological tissue, and of particular note the tandem repeats in the VNTR region of MUC6 .
Glioma - brain tumor
In the first analysis, researchers discovered highly variable and patient-specific genomic alterations in patients with diffuse gliomas. They determined that mutations are largely driven early in glioma development and diverge rapidly thereafter.
Female doctor and bald cancer patient talking in clinic examination room
For each major type of cancer treatment (radiation therapy, chemotherapy, surgery), approximately of one-third of patients experienced treatment-related side effects that they wanted more information about.
GenapSys’ sequencing system is about the size of an iPad, costs under $10,000, and is based on a proprietary direct electronic sequencing chip, which is intended to eliminate the need for cumbersome equipment.
Berg will partner with Massachusetts General Hospital and Brigham and Women's Hospital to study potential biomarkers for Alzheimer's and other neurodegenerative disorders from Harvard Biomarker Study biospecimens. [Source: ajcity.net]
The $492K award from the Alzheimer's Drug Discovery Foundation Diagnostics Accelerator will aid in the development of a blood-based test for circulating brain-enriched microRNAs as peripheral biomarkers of neurodegeneration.
Diagnostic system tests for BRCA mutations in order to assess risk of Hereditary Breast and Ovarian Cancer (HBOC) syndrome in women with breast cancer.
DNA research concept DNA barcodes for biomedical research  mitochondrial DNA  Prostate cancer DNA test
The mechanism identified suggests that when an oncogene is activated and begins to replicate itself in an uncontrolled fashion, creating multiple copies of itself within the genome (and beginning the process of turning a normal cell into a cancerous one), non-coding DNA material is included in the replication sequence.
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