One of the most commonly shared types of mutations were those affecting the microtubule-associated protein 1A gene (MAP1A), which increases risk of developing one of these conditions by more than 15 times.
Genetic expression of HNF4 has previously been shown by to be heavily influenced by the gut microbiota. This new study suggests a novel connection between HNF4A and HNF4G genes, diet, and cancer.
The researchers say this approach, which is based on structural DNA nanotechnology, could be effective against many different viruses because like Dengue, all other viruses must first attach to the cell wall to infect their host.
This study used newer sequencing methods in Genome-Wide Associated Studies (GWAS) to provide more complete genetic analysis of neurological tissue, and of particular note the tandem repeats in the VNTR region of MUC6 .
In the first analysis, researchers discovered highly variable and patient-specific genomic alterations in patients with diffuse gliomas. They determined that mutations are largely driven early in glioma development and diverge rapidly thereafter.
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For each major type of cancer treatment (radiation therapy, chemotherapy, surgery), approximately of one-third of patients experienced treatment-related side effects that they wanted more information about.
GenapSys’ sequencing system is about the size of an iPad, costs under $10,000, and is based on a proprietary direct electronic sequencing chip, which is intended to eliminate the need for cumbersome equipment.
The $492K award from the Alzheimer's Drug Discovery Foundation Diagnostics Accelerator will aid in the development of a blood-based test for circulating brain-enriched microRNAs as peripheral biomarkers of neurodegeneration.
Diagnostic system tests for BRCA mutations in order to assess risk of Hereditary Breast and Ovarian Cancer (HBOC) syndrome in women with breast cancer.
The mechanism identified suggests that when an oncogene is activated and begins to replicate itself in an uncontrolled fashion, creating multiple copies of itself within the genome (and beginning the process of turning a normal cell into a cancerous one), non-coding DNA material is included in the replication sequence.