If data are the new oil, then the precision medicine engine isn’t going to seize up any time soon. We are at a point in time where the use of real-world data and the evidence generated from those data is gaining momentum in the healthcare industry, but it is critical that we build the tools to extrapolate accurate meaning while identifying any potential for bias. Importantly, this includes continuously interrogating the provenance and relevance of the data and how they relate to specific diseases or individual patients. In addition to improving healthcare for individuals, real-world evidence (RWE) is being used to improve how scientists run clinical trials, by selecting the most appropriate participants and trial sites. Another area that RWE is being used is in health equity. What matters here are the nonclinical parameters that affect equitable access to healthcare—what is more commonly termed social determinants of health.