REGISTER NOW Broadcast Date: September 12, 2019 Time: 8:00 am PT, 11:00 am ET, 17:00 CET BRCA1/BRCA2 genes represent the best examples for our current understanding of the molecular genetics of cancer. Studying germline mutations in BRCA1,...
The findings suggest that tumor development can span the entire lifetime of an individual, so the mutations that initiate cancer progression may arise decades before diagnosis.
The investment allows Seqster to ramp up development of its technology which streamlines patient recruitment for clinical trials by matching consenting patients based on their EHR, genomic, and real-time digital data delivered by wearable monitoring devices.
The Phase I clinical trial to evaluate CRISPR-Cas9-edited T cells in humans with advanced cancer, led by immunotherapy pioneer Carl June, has reported the patients experienced no negative side effects, and that the engineered T cells persisted in their bodies for months.
As demand continues to grow for more data to inform precision medicine, digital biomarkers represent a new class of biomarkers that provide information in real time.
Women whose plasma contained circulating tumor DNA had only a 56% chance of being cancer-free two years following chemotherapy and surgery, while those without it had an 81% chance the cancer would not return in the same time span.
The researchers found that a protein known as β-arrestin2 increases the accumulation of the neurotoxic tau tangles that cause several forms of dementia, by interfering with the process that cells use to remove excess tau from the brain.
Up-and-Coming Diagnostic Test Developers Emerge as Consolidation Thins the Field.
Combining wearable devices, handheld devices and digital apps lets researchers tell the difference between people with early dementia and those without it.
Leading open-source tools, GATK and DRAGEN, are being combined to create a cutting-edge software suite for methods including small variant (SNV) and large variant...
When tested in cancer-bearing mice, a single dose of the bacteria continuously produced and released the anti-PD-L1 and anti-CTLA-4 nanobodies, triggering an immune response that led to tumor regression. The researchers say the platform could be used to deliver multiple immunotherapies simultaneously, enabling the release of effective therapeutic combinations for hard-to-treat cancers.
OncoDNA said the financing is designed to support rapid international growth, accelerate software development, and carry out hiring initiatives.
This look at endometrial cancer offers insights to better identify which patients will need aggressive treatment and which won't, clues on why certain treatments are not effective with some patients, and suggestions for drugs to target proteins CDK12, SMARCA4, and PML.
A new study has identified MIR1249 as a key player in genetically altering cancer cells to become resistant to chemotherapy, a discovery that opens the possibility it could be a more favorable biomarker to target than more conventional treatments that block proteins.
Cell phone users with single nucleotide polymorphisms (SNPs) in four of the genes studied were more than two times more likely to develop cancer. Overall, the researchers found 10 SNPs that appear to increase the risk of thyroid cancer among cell phone users.