Cancer Gene Variant Detection Using a Pre-Optimized Sample to Report Workflow

REGISTER NOW Broadcast Date: September 12, 2019 Time: 8:00 am PT, 11:00 am ET, 17:00 CET BRCA1/BRCA2 genes represent the best examples for our current understanding of the molecular genetics of cancer. Studying germline mutations in BRCA1,...

Somatic Mutations at Root of Some Cancers Apparent Years Before Onset

The findings suggest that tumor development can span the entire lifetime of an individual, so the mutations that initiate cancer progression may arise decades before diagnosis.

Takeda Invests in Patient-Centric Health Data Company Seqster

The investment allows Seqster to ramp up development of its technology which streamlines patient recruitment for clinical trials by matching consenting patients based on their EHR, genomic, and real-time digital data delivered by wearable monitoring devices.
CRISPR technology

CRISPR-Edited T Cells Clear First Hurdle in Cancer Clinical Trial

The Phase I clinical trial to evaluate CRISPR-Cas9-edited T cells in humans with advanced cancer, led by immunotherapy pioneer Carl June, has reported the patients experienced no negative side effects, and that the engineered T cells persisted in their bodies for months.
binary code pattern

The Biomarker Future is Digital

As demand continues to grow for more data to inform precision medicine, digital biomarkers represent a new class of biomarkers that provide information in real time.
Light micrograph of metastases in breast tissue

Triple Negative Breast Cancer Recurrence Prediction Method Developed

Women whose plasma contained circulating tumor DNA had only a 56% chance of being cancer-free two years following chemotherapy and surgery, while those without it had an 81% chance the cancer would not return in the same time span.
Berg will partner with Massachusetts General Hospital and Brigham and Women's Hospital to study potential biomarkers for Alzheimer's and other neurodegenerative disorders from Harvard Biomarker Study biospecimens. [Source:]

Protein that Prevents Tau Clearance Linked to AD and Other Tau Tangle Proteinopathies

The researchers found that a protein known as β-arrestin2 increases the accumulation of the neurotoxic tau tangles that cause several forms of dementia, by interfering with the process that cells use to remove excess tau from the brain.
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20 Molecular Diagnostics Companies to Watch

Up-and-Coming Diagnostic Test Developers Emerge as Consolidation Thins the Field.
elderly man with head breaking apart

Feasibility Study Finds Informative Digital Biomarkers of Dementia

Combining wearable devices, handheld devices and digital apps lets researchers tell the difference between people with early dementia and those without it.
To make better use of genomics data

Illumina and the Broad Co-Developing Open-Source Secondary Analysis Software

Leading open-source tools, GATK and DRAGEN, are being combined to create a cutting-edge software suite for methods including small variant (SNV) and large variant...
T cell populations in colorectal tumor tissue.

Engineered Probiotic Can Deliver Immune Checkpoint Inhibiting Nanobodies Directly to Tumors

When tested in cancer-bearing mice, a single dose of the bacteria continuously produced and released the anti-PD-L1 and anti-CTLA-4 nanobodies, triggering an immune response that led to tumor regression. The researchers say the platform could be used to deliver multiple immunotherapies simultaneously, enabling the release of effective therapeutic combinations for hard-to-treat cancers.

Precision Oncology Company OncoDNA Closes $20M Series B Financing

OncoDNA said the financing is designed to support rapid international growth, accelerate software development, and carry out hiring initiatives.
Uterus Cancer

New Study Reveals Dozens of Pathways in Endometrial Cancer Development

This look at endometrial cancer offers insights to better identify which patients will need aggressive treatment and which won't, clues on why certain treatments are not effective with some patients, and suggestions for drugs to target proteins CDK12, SMARCA4, and PML.
Cancer Chemotherapy Patient Reading Smart Phone

Recently Discovered miRNA Could Change Chemotherapy Landscape

A new study has identified MIR1249 as a key player in genetically altering cancer cells to become resistant to chemotherapy, a discovery that opens the possibility it could be a more favorable biomarker to target than more conventional treatments that block proteins.
Businessman using mobile phone in office hallway

Cell Phone Use and Genetic Variations Linked in Thyroid Cancer Study

Cell phone users with single nucleotide polymorphisms (SNPs) in four of the genes studied were more than two times more likely to develop cancer. Overall, the researchers found 10 SNPs that appear to increase the risk of thyroid cancer among cell phone users.
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