The NovaSeq S4 flow cell reagent kit and NovaSeq Xp workflow, for its NovaSeq™ 6000 System, extend the capabilities of the NovaSeq platform to enable high-intensity sequencing across a wide range of sequencing methods. NovaSeq S4 flow cell delivers up to 6TB of output in two days and is suited for high-intensity sequencing applications. The S4 is geared toward larger sample numbers and will enable experiments such as 200x to 300x whole genome tumor profiling. Users can sequence up to 48 human genomes, or 384 exomes per run in less than 48 hours, paving the way for large-population-scale initiatives. The NovaSeq Xp workflow comprises the NovaSeq Xp flow cell loading dock and reagents, which enables users to load libraries directly into individual lanes of the flow cells. Users can partition samples and projects by lane whether mixing library types or implementing novel approaches to sample indexing. The NovaSeq S4 flow cells are shipping immediately while the NovaSeq Xp workflow components are expected to ship before the end of the year.