Regeneron’s COVID-19 Antibody “Cocktail” Granted Emergency Use Authorization by FDA
Before patients can be treated with REGEN-COV2 under the EUA, they must weigh at least 40 kilograms (about 88 pounds) and be deemed at high risk for progressing to severe COVID-19 and/or hospitalization. That high-risk category includes adults who are ages 65 or older, or who have chronic medical conditions.
New Insights on Tau’s Spread in Brain and Impact of Genetic Risk Revealed
Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s disease (AD) and other tauopathies, but this study aimed to reveal more about how neuroanatomical connections, spatial proximity, and regional vulnerability affect this process.
Direct RNA Amplification Reagents
The new automation friendly reagents allow laboratories testing for COVID-19 have a tool that allows them to skip the RNA extraction step of the many testing workflows and move directly to PCR amplification.
Alzheimer’s DNA Methylation Study Uncovers 84 New Genes Associated with the Disease
The meta-analysis, believed to be the largest of its type, reviewed six earlier DNA methylation studies of AD, which represented brain tissue studies of 1,453 individuals.
New Study Shows COVID-19 Vaccine from J&J Is Effective Against Variants of Concern
In the three months since J&J’s COVID-19 vaccine received emergency use authorization from the FDA, more than 10 million Americans have received the vaccine, according to the Centers for Disease Control and Prevention.
“Bad” Fat Hinders Killer T Cells’ Ability to Fight Cancer
While scientists know that tumors accumulate fats and that the accumulation is associated with immune dysfunction, the details of the relationship were not fully understood. The new findings suggest that the tumor microenvironment contains an abundance of oxidized fat molecules that suppress killer T cells’ ability to kill cancer cells when ingested.
Gene Behind Childhood Bone Cancer Uncovered
Research shows that the gene OTUD7A controls a cancer-causing protein in Ewing sarcoma bone cancer and that it's possible to block the activity of this oncoprotein, revealing a new drug candidate for treating this type of cancer.
Leprosy Drug Shows Potential as At-Home Treatment for COVID-19
Clofazimine, which was discovered in 1954, is FDA approved and on the World Health Organization’s List of Essential Medicines. The drug’s utility for COVID-19 was initially identified by screening more than 12,000 drugs from the ReFRAME drug library.
More Evidence Found of Colon Cancer’s Link to a High-Fat Diet
The researchers examined the proposed link between peroxisome proliferator-activated receptor (PPAR) and how it promotes regeneration and tumorigenesis by enhancing intestinal stem cell numbers, proliferation, and function.
Single-cell RNA Sequencing Reveals Kidney Cancer Cellular Origins
Along with identifying these putative cell of origin for a variety of RCCs, the analysis also revealed pathways and interactions within the tumor microenvironment that predicted whether the tumor would respond to immunotherapy.
Prime Time for the Microbiome
With some positive results in the clinic, there are other encouraging signs the field is maturing and branching into other therapeutic areas such as oncology.
RNA for Medical Analysis
From Mendelian disorders to COVID-19, academic and industrial scientists use these nucleic acids to help diagnose diseases.
Top Women in Precision Medicine
In our second installment of women making their mark in the field, Clinical OMICs interviews Bonnie Anderson of Veracyte, Tina Hambuch of Invitae, and Cindy Perettie of Foundation Medicine.
Saving Baby Nathan
California Medicaid’s pilot program Project Baby Bear delivers better outcomes at lower cost via rapid whole-genome sequencing of critically ill newborns.
Payer Policies not Sole Reason for Inconsistent Utilization of Genomic Testing
A report from the Personalized Medicine Coalition found significant variability in the use of genomic testing for patients not only from state to state, but also within states.
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