Twist Bioscience has developed the Twist Respiratory Virus Research Panel, a next-generation sequencing (NGS) approach to detecting a wide range of respiratory diseases including SARS-CoV-2, several other coronaviruses, influenzas, rhinoviruses and respiratory syncytial virus. The panel includes both RNA-based and DNA-based viruses in one kit with 41,047 nucleic acid probes. It allows researchers to separate COVID-19 symptoms from those of other respiratory illnesses, both influenza- and non-influenza-related. The probes within the panel cover both viral genomes and their reverse complements. The panel is optimized for standard and FastHyb or Fast Hybridization workflows, resulting in uniformity after capture with FOLD 80 base penalty in the range of 1.2 to 1.5 for the synthetic viral targets. The panel is able to detect as little as 100 copies of viral material, and has coverage of > 99.9% of the genome at 1X or greater post-enrichment.