Epigenetic Factors Predicting More Severe COVID-19 Revealed

A Spanish study shows epigenetic markers in the DNA can predict COVID-19 disease severity. Many of these markers are found in genes linked to immune function and the release of interferon in response to viral infection such as AIM2 and HLA-C.

Leprosy Drug Shows Potential as At-Home Treatment for COVID-19

Clofazimine, which was discovered in 1954, is FDA approved and on the World Health Organization’s List of Essential Medicines. The drug’s utility for COVID-19 was initially identified by screening more than 12,000 drugs from the ReFRAME drug library.
Antibodies responding to coronavirus particles, illustration

Multi-Omic Study Explains Differences in COVID-19 Immune Response

Patients with severe COVID-19 have high levels of immune cells that increase inflammation and promote blood clots and low levels of infection-fighting B and T cells, according to a U.K. study using multi-omics techniques.
Body with stomach tumor

FDA Approves First Immunotherapy for Initial Treatment of Gastric Cancer

The PD-1 checkpoint inhibitor Opdivo (nivolumab) has been approved by the FDA as an initial treatment for advanced gastric cancer, adding to its approvals as a treatment for melanoma and a number of other cancers.
A wristwatch-like device measures cytokine levels in passive sweat

Sweat Sensor Could Predict Cytokine Storm in COVID-19 Patients

A new sweat sensor can detect seven inflammatory proteins seen at high levels in patients experiencing the kind of extreme immune reaction seen in COVID-19 and in some flu patients, which researchers hope will speed up treatment.

Risk of Lung Cancer Linked to Specific Variants

The researchers identified 25 new rare pathogenic variants associated with lung cancer susceptibility and validated five of those variants. Of those five, two variants involved genes with known connections to lung cancer risk, ATM and MPZL2. Three variants involved novel lung cancer susceptibility genes, POMC, STAU2 and MLNR.
Coronavirus infection of lungs, conceptual illustration

Nebulizer Can Deliver CRISPR-Based Treatment Targeting COVID-19 and Influenza

The researchers used mRNA technology to code for Cas13a, which destroys parts of the RNA genetic code that viruses use to replicate in cells in the lungs. Using a guide strand, researchers can provide a map that basically tells the Cas13a protein where to attach to the viruses’ RNA and begin to destroy it.
Biodesix has expanded its lung disease test franchise by acquiring Intagrated Diagnostics (Indi)

New Genetic Markers of Lung Cancer Could Lead to More Personalized Treatments

The researchers found that mutations in KMT2C and KMT2D make non-small cell lung cancer more sensitive to Poly (ADP-ribose) polymerase (PARP) inhibitors, which are already approved for treating prostate, pancreatic, ovarian, and breast cancer patients.
Gut-brain connection or gut brain axis. Concept art showing a connection from the gut to the brain. 3d illustration.

Gut Microbes That Influence Neurological Disorders May Inspire New Therapies

Researchers at the Baylor College of Medicine report that they have found that microbes in the gut may contribute to certain symptoms associated with complex neurological disorders, which also suggests that microbe-inspired therapies may one day help to treat them.

Machine Learning Method Predicts New Cancer Genes

Known as Explainable Multi-Omics Graph Integration (EMOGI), the machine learning method predicted 165 new cancer genes by combining multiomics pan-cancer data—such as mutations, copy number changes, DNA methylation and gene expression—together with protein–protein interaction (PPI) networks.

U.S. Agencies Push for Pause of J&J COVID-19 Vaccine After Patients Develop Rare Blood...

The CDC’s Advisory Committee on Immunization Practices (ACIP) will meet Wednesday to review the six reported cases to assess their potential significance. The FDA plans to conduct its own investigation and will also review the CDC’s analysis.
Coronavirus, virus, flu, bacteria close-up. Abstract 3D rendered illustration

Intestinal Organoids Developed to Test New Drugs for COVID-19

SARS-CoV-2 affects many parts of the body. Although the primary manifestations of COVID-19 involve the respiratory system, gastrointestinal effects may play a critical role in both disease severity and transmission.
Alzheimer's disease: the amyloid-beta peptide accumulates to amyloid fibrils that build up dense amyloid plaques.

Increasing ABCC1 Gene Expression Could Help Prevent Alzheimer’s Disease

The ABCC1 protein has the ability to break down amyloid plaques in Alzheimer’s disease and researchers show in a new study that increasing expression of this gene may even prevent the neurodegenerative disease from developing in the first place.
Pancreatic cancer, malignant tumor of pancreas

Metabolic Profiling for Pancreatic Cancer Predicts Patient Outcomes

A team of researchers from Centre de Recherche en Cancerologie de Marseille (CRCM), INSERM in France have developed a new method for capturing the metabolic signature of pancreatic ductal adenocarcinoma to predict clinical outcomes.
Scientists conducting the process of Polymerase chain reaction (PCR) to amplify DNA by using a thermocycler to create samples

Direct RNA Amplification Reagents

The new automation friendly reagents allow laboratories testing for COVID-19 have a tool that allows them to skip the RNA extraction step of the many testing workflows and move directly to PCR amplification.
Precision for Medicine has acquired machine learning-based technology developer SimplicityBio for an undisclosed price

Machine Learning Algorithm Predicts Cancer Drug Efficacy

A method known as 'Drug Ranking Using Machine Learning' was developed at Queen Mary University in London and is based on machine learning analysis of protein omics data in cancer cells. It was created based on training responses of cancer cells to a panel of cancer drugs and can predict the most appropriate one to use to treat a particular cancer.
Source: Busakorn Pongparnit/Getty Images

Oncology Analytics’ Series B Yields $21M

The company will expand its health benefits management offerings, as well as make investments in data analytics and innovative health tech
Pancreatic cancer, malignant tumor of pancreas

New Biomarker of Pancreatic Cancer May Predict Benefit of Tumor-Penetrating Peptide

According to the new study, the tumor-penetrating peptide known as iRGD appears to enhance the effects of chemotherapy, reducing metastasis, and increasing survival, to a degree determined by levels of β5 integrin. Essentially, β5 integrin gives chemotherapeutic agents the opportunity to destroy the tumor from within.
Seamless pattern of hand drawn faces of various ethnicities

Genetic Ancestry Testing Useful for Health Planning

The research team drew from Mount Sinai's BioMe BioBank program, a repository of genomic information for diverse populations, for its study. Using machine learning methodology, they identified 17 distinct ethnic communities from among the 30,000 participants in the BioMe BioBank.
Molecule of DNA forming inside the test tube equipment.3d rendering,conceptual image.

cfDNA Extraction Kits

The kit is designed for purification of circulating cfNDA and uses silica coated paramagnetic particles to purify cfDNA from less than 1 mL to greater than 10 mL of serum or plasma.
Coronavirus structure

Interferon-Stimulated Genes Limit SARS-CoV-2 Infection

The researchers’ analysis showed low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease. Also, transcriptome-wide association in lung tissue revealed that high expression of the monocyte–macrophage chemotactic receptor CCR2 is associated with severe COVID-19.

Biognosys, Siemens Healthineers Collaborate on Diagnostic Biomarker Development

Under the agreement, Biognosys will leverage its biomarker discovery technologies in conjunction with Siemens’ biomarker assay development, lab testing, and commercialization infrastructure to discover novel biomarkers followed by translation of the biomarkers into validated assays for potential clinical applications.
Human dark brown eyes close-up.  Side look

Genetically-Caused Blindness Reversed with Single Injection of Antisense Therapeutic

Almost a dozen antisense treatments have been approved by the FDA to date. Almost all of these are for orphan diseases, including the drug used in this study sepofarsen, which targets Leber congenital amaurosis (LCA), but is specifically designed for LCA patients with the CEP290 mutation.
DNA strand

Emory Study Identifies Genes and Proteins Linked to Depression

A new approach developed at Emory University School of Medicine combines genome-wide association study data with human brain proteomic data and has identified 19 genes and 25 brain proteins that could cause depression.
Compassionate nursing care

Genome Sequencing Reveals Patterns of COVID-19 Spread in Elder Care Homes

The researchers conclude that isolating residents or staff when they develop symptoms is not sufficient to prevent within-care home spread once the virus has entered the care home. Certain measures may be required on an ongoing basis within care homes when there is sustained community transmission, even when no outbreak is suspected.
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