The researchers looked at whether three specific biomarkers, previously implicated in learning and memory, would increase in older adults following exercise and correlate with cognition and metabolomic markers of brain health.
Inhibition of the NAMPT enzyme pushes triple negative breast cancer cells towards apoptosis and adding compounds that block anti-apoptotic proteins ensures cancer cell death, presenting a new treatment opportunity for these patients.
Biogen’s adeno-associated virus-based gene therapy for treatment of the degenerative blindness choroideremia has failed at Phase III, the second ophthalmic gene therapy trial to fail for the company.
A wider reach—in patients and data—promises better outcomes.
The study could signal a potential treatment breakthrough for patients with this form of breast cancer, which disproportionately affects and tends to develop more aggressively in black women.
Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s disease (AD) and other tauopathies, but this study aimed to reveal more about how neuroanatomical connections, spatial proximity, and regional vulnerability affect this process.
The meta-analysis, believed to be the largest of its type, reviewed six earlier DNA methylation studies of AD, which represented brain tissue studies of 1,453 individuals.
In the three months since J&J’s COVID-19 vaccine received emergency use authorization from the FDA, more than 10 million Americans have received the vaccine, according to the Centers for Disease Control and Prevention.
While scientists know that tumors accumulate fats and that the accumulation is associated with immune dysfunction, the details of the relationship were not fully understood. The new findings suggest that the tumor microenvironment contains an abundance of oxidized fat molecules that suppress killer T cells’ ability to kill cancer cells when ingested.
The new automation friendly reagents allow laboratories testing for COVID-19 have a tool that allows them to skip the RNA extraction step of the many testing workflows and move directly to PCR amplification.
Research shows that the gene OTUD7A controls a cancer-causing protein in Ewing sarcoma bone cancer and that it's possible to block the activity of this oncoprotein, revealing a new drug candidate for treating this type of cancer.
Clofazimine, which was discovered in 1954, is FDA approved and on the World Health Organization’s List of Essential Medicines. The drug’s utility for COVID-19 was initially identified by screening more than 12,000 drugs from the ReFRAME drug library.
The researchers examined the proposed link between peroxisome proliferator-activated receptor (PPAR) and how it promotes regeneration and tumorigenesis by enhancing intestinal stem cell numbers, proliferation, and function.
Along with identifying these putative cell of origin for a variety of RCCs, the analysis also revealed pathways and interactions within the tumor microenvironment that predicted whether the tumor would respond to immunotherapy.
The first four million doses are expected be distributed across the United States this week, with 100 million doses set to be delivered by the end of June. Unlike the Pfizer/BioNTech and Moderna vaccines, J&J’s vaccine requires only a single dose.
The researchers identified 25 new rare pathogenic variants associated with lung cancer susceptibility and validated five of those variants. Of those five, two variants involved genes with known connections to lung cancer risk, ATM and MPZL2. Three variants involved novel lung cancer susceptibility genes, POMC, STAU2 and MLNR.
The kit is designed for purification of circulating cfNDA and uses silica coated paramagnetic particles to purify cfDNA from less than 1 mL to greater than 10 mL of serum or plasma.
The researchers used mRNA technology to code for Cas13a, which destroys parts of the RNA genetic code that viruses use to replicate in cells in the lungs. Using a guide strand, researchers can provide a map that basically tells the Cas13a protein where to attach to the viruses’ RNA and begin to destroy it.
Upon regulatory approvals, Novavax said, it is on course to reach manufacturing capacity of 100 million doses per month by the end of the third quarter and 150 million doses per month by the end of the fourth quarter.
New findings support directed germline testing for inherited cancer predisposition in all patients with advanced cancer and also support the use of integrative genomic profiling as a component of standard of care for patients with cancer of unknown origin and other rare malignant neoplasms.
Researchers at the Baylor College of Medicine report that they have found that microbes in the gut may contribute to certain symptoms associated with complex neurological disorders, which also suggests that microbe-inspired therapies may one day help to treat them.
The company will expand its health benefits management offerings, as well as make investments in data analytics and innovative health tech
Inhibiting bacterial hydrogen sulfide production can help improve antibiotic efficacy by reducing the ability of bacterial species such as Staphylococcus aureus and Pseudomonas aeruginosa to tolerate exposure to antibacterial drugs.
The analysis from the Human Genome Sequencing Center at Baylor College of Medicine revealed nearly 77% of the discordant variants were clustered within sections of the genome with known assembly problems that the researchers called DISCordant Reference Patches (DISCREPs).
In today’s world of precision medicine, the more information you have on a patient, the better, in terms of treatment options. The field of...