Pancreatic cancer, malignant tumor of pancreas

Multi-Omic Approach to Pancreatic Cancer Reveals New Disease Signatures

The comprehensive and integrated proteogenomic characterization is a valuable resource for the development of early detection strategies and identifies several promising new targets for pancreatic ductal adenocarcinoma treatment and early diagnosis.
Conceptual image for viral ethiology of prostate cancer

Paige Prostate Nabs First FDA Approval of AI-Based Pathology Tool for Cancer Dx

A clinical study evaluated by the FDA found that Paige Prostate improved detection of cancer on individual slide images by 7.3% on average when compared to pathologists’ unassisted reads for whole slide images of individual biopsies, with no impact on the read of benign slide images.
Lymphoma cancer cell, SEM

AI Can Help Diagnose Blood Cancer Even in Resource Poor Settings

A deep learning AI system designed by German researchers can help analyze flow cytometry data from different machines and labs and aid clinicians with making blood cancer diagnoses even if they only have access to minimal bioinformatics resources.

Enzymatic Fragmentation Library Preparation Kit

The kit is optimized for challenging NGS applications including liquid biopsy, somatic variant testing and genome-wide association studies.
Memory doubts

New Drug Targets for AD, ALS, and Parkinson’s Revealed by Brain Proteome Atlas

A genomic atlas of proteins found in the brain of Alzheimer’s disease patients has helped identify new targets for treating Alzheimer’s, Parkinson’s, ALS, and stroke; and 29 drugs, already approved by the FDA for other indications, could be used to target these conditions.

Leprosy Drug Shows Potential as At-Home Treatment for COVID-19

Clofazimine, which was discovered in 1954, is FDA approved and on the World Health Organization’s List of Essential Medicines. The drug’s utility for COVID-19 was initially identified by screening more than 12,000 drugs from the ReFRAME drug library.
Beaty woman clor eye closeup supermacro background

Immunocore’s T-Cell Receptor Therapy Succeeds in Phase III

Immunocore's tebentafusp is the first T-cell receptor and the first systemic therapy that shows a significant survival benefit for patients with metastatic uveal melanoma, according to results from a Phase III trial.
corona virus 1

WHO Gaffe Releases Data Showing Remdesivir not Effective Against COVID-19

According to the draft, remdesivir had not reduced the presence of SARS-CoV-2 in the bloodstream of 158 patients treated with the antiviral candidate in the 237-patient trial and 18 patients were taken off the drug due to side effects.
Lung cancer, close-up

More Precise NSCLC Treatment Selection Boosted by Using EGFR Mutation Structure and Function

Researchers from The University of Texas MD Anderson Cancer Center say that grouping epidermal growth factor receptor (EGFR) mutations by structure and function can help to better match non-small cell lung cancer (NSCLC) patients to the most promising treatments.
Astrocytes; neuroglial cells, 250X at 35mm. Shows: processes (perivascular feet) of neuroglial cells in contact with a brain capillary. These cells may help to form the blood-brain barrier to drugs, antibiotics, etc.

Blood-Brain Barrier Disruption Promotes Tumor Lethality

Researchers found that blocking the activity of IL-6 at the blood-brain barrier increased the lifespan of fruit flies with cancer by 45% and also found that after 21 days, 75% of cancer-carrying lab mice treated with an IL-6 receptor blocker were alive, versus only 25% of untreated mice.
nurse in protective gear examining a patient

GWAS Reveals Multiple Host Genes Linked to Severe COVID-19 Symptoms

Of the 13 loci identified so far by the team, two had higher frequencies among patients of East Asian or South Asian ancestry than in those of European ancestry, underscoring the importance of diversity in genetic datasets.

Small Sequencer Developer GenapSys Completes $90M Series C Financing

GenapSys’ sequencing system is about the size of an iPad, costs under $10,000, and is based on a proprietary direct electronic sequencing chip, which is intended to eliminate the need for cumbersome equipment.
Picture of the start of the ESMO21 virtual cancer conference - stage with speakers and podium

ESMO 2021: Cancer Research and Drug Development Highlights

Research highlights from ESMO21 included results from Phase III DESTINY-Breast03 trial (AZ, Daiichi Sankyo), Phase II KRYSTAL-1 lung cancer study (Mirati Therapeutics), Phase III CheckMate 649 (Bristol Myers Squibb), and the Phase III KEYNOTE-826 trial.
Neuroblastoma cell line labeled with fluorescent molecules

New Potential “Double Target” Immunotherapy in Neuroblastoma Uncovered

A new immunotherapy using modified cells targeting two different antigens was highly effective in a mouse model of human neuroblastoma, according to a study led by researchers from the UNC Lineberger Comprehensive Cancer Center and the UNC School of Medicine.
DNA and RNA molecules

Graphene Hydrogel Could Help mRNA Vaccine Target Cancer More Effectively

A specialized hydrogel can not only encapsulate and protect mRNA cancer vaccines from being broken down in the body, but can also target lymph nodes to activate immune cells, shows early stage research.
Fatty liver, conceptual illustration

TGen Study Pinpoints Biomarkers for Non-Alcoholic Fatty Liver Disease

The researchers identified differences in DNA methylation (DNAm) that accurately predicted different stages of liver fibrosis in as many as 94% of patients with non-alcoholic fatty liver disease (NAFLD), according to the study published in the journal Clinical Epigenetics.
Corona Virus Covid-19 Medical Vaccine Concept.

Cancer Vaccine Effectiveness May Lie in Reawakening Dormant T-Cells

MIT researchers revealed that vaccinating against certain neoantigens can boost overall T-cell response by reawakening dormant T cell populations that target those proteins and help shrink tumors in mice.
Coronavirus, virus, flu, bacteria close-up. Abstract 3D rendered illustration

COVID-19 Antibodies Derived from Llamas Show Therapeutic Potential

The nanobodies, which bind tightly to the SARS-CoV-2 virus, neutralizing it in cell culture, could provide a cheaper and easier to use alternative to human antibodies taken from patients who have recovered from COVID-19.
Image on screen of cancer screen. Artificial intelligence (AI) can be used in software that helps a pathologist interpret features of cancer in digitized images of samples.

AI For Cancer Detection: Ready for Prime Time or Caution Advised?

AI-based cancer imaging diagnostics have improved enormously over the last few years, with some programs already in use in the clinic, but researchers advise caution with more widespread rollout until more large-scale testing is completed.
corona virus 1

COVID-19 Antiviral Candidate Targeting RNA Replicase Developed

U.S. researchers have developed an antiviral candidate drug targeting iron-sulfur clusters needed for SARS-CoV-2 RNA replicase to function properly and for the virus to reproduce successfully.
Image of researchers in a lab adding samples to a Helix sequencing machine.

Helix, MUSC to Launch Population Health Genomics Initiative in South Carolina

A new genomics program in South Carolina will enroll 100,000 volunteers over 4 years who will undergo exome testing to provide useful health information to the patients and their clinicians from the start, while also contributing to medical research.
RNA Polymerase II transcribing DNA, illustration

Newly Discovered Checkpoint Mechanism Fine Tunes Gene Transcription

Disruption of the mechanism leads to unrestricted gene transcription and is implicated in cancer, say the scientists. The study points to new opportunities for therapeutic intervention by demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies.
Gut-brain connection or gut brain axis. Concept art showing a connection from the gut to the brain. 3d illustration.

Gut Microbes That Influence Neurological Disorders May Inspire New Therapies

Researchers at the Baylor College of Medicine report that they have found that microbes in the gut may contribute to certain symptoms associated with complex neurological disorders, which also suggests that microbe-inspired therapies may one day help to treat them.
Sickle cell anemia

Mitochondrial DNA Triggers Inflammation in Sickle Cell Anemia Patients

Mitochondrial DNA fragments in the blood are a trigger for inflammation in people with sickle cell disease, suggests new research. The red blood cells of people with this chronic condition seem to accumulate mitochondria, which are absent from healthy blood cells. When these organelles break up their DNA is also broken up and found circulating in the blood.
DNA sequencing

Entire Genomes Can Now Be Assembled Quickly on a Personal Computer

An innovative bioinformatics approach developed at MIT and the Institute Pasteur allows genomes to be assembled within minutes on a standard desktop computer, a process that normally takes many hours and uses high amounts of computing power.